Publikationsdatum:
1979-10-05
Beschreibung:
The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero-Munoz, F -- de Lourdes Guerrero, M -- Way, E L -- Li, C H -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39340" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Biological Transport/drug effects
;
Calcium/*metabolism
;
Dose-Response Relationship, Drug
;
Drug Tolerance
;
Endorphins/antagonists & inhibitors/*pharmacology
;
Male
;
Mice
;
Naloxone/pharmacology
;
Neurotransmitter Agents/metabolism
;
Rats
;
Synaptosomes/*drug effects/metabolism
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
Permalink
