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  • Springer  (1,774)
  • 1975-1979  (1,157)
  • 1965-1969  (617)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Studies on the stability of bPTH (1–84) and bPTH (1–34) receptor complexes by measuring the hormone-induced lactate fluxes of embryonic mouse calvariain vitro (1976)
    Springer
    Calcified tissue international 22 (1976), S. 158-163 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064058
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  • 2
    Electronic Resource
    Electronic Resource
    Seasonal variations of hydrographic conditions of estuarine and oceanic waters adjoining the old Mangalore port (1979)
    Springer
    Pure and applied geophysics 117 (1979), S. 935-942 
    Details
    ISSN: 1420-9136
    Keywords: Estuary ; Hydrographic conditions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract In order to understand the various processes responsible for siltation in the entrance channel and in the sand bar area near the old Mangalore port, variations in temperature, salinity, suspended sediment load, currents and extinction coefficient in the Netravathi-Gurpur Estuary and in the sea near the sand bar were studied in relation to tides during monsoon, post-monsoon and pre-monsoon seasons. The hydrographic characteristics in the estuary showed marked seasonal changes and were influenced by tides to a considerable extent. In the sea, seasonal variations of these parameters were less marked, and the effect of tides was not significant. Salinity and temperature values in the estuary and in the sea were maximum during the pre-monsoon season in general. The suspended sediment load values were always higher in the estuary than in the sea and they were found to be maximum in the monsoon season. Currents in the estuary were controlled by tides as well as by the river flow, particularly in the monsoon season, whereas currents in the sea mostly followed the general circulation pattern. Extinction coefficient values were higher in the monsoon season both in the estuary and in the sea due to increase in the particulate matter from inland drainage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00876077
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  • 3
    Electronic Resource
    Electronic Resource
    Biological calcium phosphates and their role in the physiology of bone and dental tissues I. Composition and solubility of calcium phosphates (1978)
    Springer
    Calcified tissue international 26 (1978), S. 127-137 
    Details
    ISSN: 1432-0827
    Keywords: Calcium phosphates ; Composition ; Dissolution ; Precipitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Variations in the composition of bone and tooth mineral are consistent with the model that the constituents are a mixed microcrystalline apatite (AP)-octocalcium phosphate (OCP) like phase and an amorphous or submicrocrystalline calcium phosphate (ACP) like phase whereby these phases can occur in different proportions. An appropriate model for a description of the variable composition and the solubility behavior of the apatite phase is given by the formula $$\begin{array}{*{20}c} {\begin{array}{*{20}c} {Ca_{5 - x - y - u} Na_{\frac{2}{3} y} } \\ {\{ (PO_4 )_{3 - x - y } (CO)_{x + y} \} (H_2 O)_{y + z} OH_{1 - x - \frac{1}{3} y - 2u} } \\\end{array}} \\\end{array}$$ in which the compositional parameters x, y, z, and u each account for one type of defect mechanism. Other point defects are formed as well by incorporation of minority amounts of ions such as Cl−, K+, and F−; a number of trace elements can substitute for Ca2+ ions under in vivo conditions. It is suggested that the incorporation of ions in or loss from the crystals in contact with aqueous solutions is reversible. Literature data are used to show the direction in which the solubility product of the apatite phase shifts by incorporation of the different physiologically relevant ions. A quantitative evaluation of the available literature data revealed that Na+ and CO3 = incorporation is the main cause for shifts in the solubility product of biological apatites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013247
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of 1,25-dihydroxycholecalciferol on embryonic bone in vitro: A biochemical and histological study (1978)
    Springer
    Calcified tissue international 25 (1978), S. 111-118 
    Details
    ISSN: 1432-0827
    Keywords: Embryonic bone ; 1,25(OH)2D3 ; PTH ; Resorption ; cAMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Explants from embryonic rat and mouse calvaria were cultivated in the presence of different concentrations of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3). The bone resorbing effects of the vitamin D3 metabolite were evaluated by measuring the release of calcium, phosphate, lactate and citrate into the culture medium after 24 h of cultivation. The influence on bone morphology was studied using embryonic mouse radii, in which histological phenomena in the bony, cartilagenous and connective tissue compartments were observed. Both kinds of experiments show that 1,25-(OH)2D3 has effects on embryonic bone which are typical for high concentrations of parathyroid hormone (PTH). However, the maximal effects on calcium release and on histology are 2.5 times less than those of PTH. In addition, some of the histological features such as the effects on epiphyseal cartilage and on osteoclasts were not observed. 1,25-(OH)2D3 in concentrations up to 2×10−9 M does not affect basal or PTH-stimulated cAMP levels in embryonic rat calvaria. In a concentration of 1×10−8 M, however, a significant decrease in PTH-stimulated cAMP production was found. It is concluded from these in vitro experiments that (1) 1,25-(OH)2D3 stimulates bone resorption, and (2) in 1,25-(OH)2D3-induced bone resorption cAMP is apparently not involved as a second messenger.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010759
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  • 5
    Electronic Resource
    Electronic Resource
    Gastrointestinal somatostatin cells in the human fetus (1976)
    Springer
    Cell & tissue research 166 (1976), S. 179-184 
    Details
    ISSN: 1432-0878
    Keywords: Gastrointestinal somatostatin cells ; Ontogenesis ; Human fetus ; Immunofluorescent reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The stomach, duodenum, jejunum and ileum from 6 to 24 week-old human fetuses or deceased premature infants and from one totally anencephalic fetus were stained with antisomatostatin serum. The somatostatin containing cells appear in different segments of the gastrointestinal tract from the tenth week of gestation. The somatostatin-containing cells are lead haematoxylin positive. Somatostatin was also detected in the duodenum of the anencephalic fetus. The study of inhibition of the immunofluorescent reaction by homologous and heterologous antigens confirmed the specificity of antiserum. These data demonstrate that somatostatin can be synthetized elsewhere than in the hypothalamus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227039
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  • 6
    Electronic Resource
    Electronic Resource
    Immunofluorescence study of LH-RH producing cells in the human fetal hypothalamus (1977)
    Springer
    Cell & tissue research 182 (1977), S. 341-345 
    Details
    ISSN: 1432-0878
    Keywords: LH-RH producing cells ; Hypothalamus ; Human fetus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The use of antibodies to synthetic LH-RH has enabled the detection by immunofluorescence of hypothalamic LH-RH producing cells in the human fetus. The perikarya of these cells are located in the pericommissural and preoptic regions, in the lamina terminalis and in the premamillary region. Reactive axons occur in the median eminence. The first LH-RH producing cells are seen as early as nine weeks of gestation. The specificity of immunocytological reaction has been controlled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219769
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  • 7
    Electronic Resource
    Electronic Resource
    Immunocytological evidence for oxytocin neurons in the human fetal hypothalamus (1978)
    Springer
    Cell & tissue research 188 (1978), S. 259-264 
    Details
    ISSN: 1432-0878
    Keywords: Hypothalamus ; Human fetus ; Oxytocin ; Neurophysin ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The use of antibodies against oxytocin or neurophysin enabled the detection by immunocytochemistry of oxytocin-neurophysin neurons in the hypothalamus in the human fetus. The perikarya of these neurons are located in the paraventricular and supraoptic nuclei. Immunoreactive neurons occur in the median eminence. The neurophysin immunoreactive neurons were more numerous than the oxytocin immunoreactive neurons. The specificity of the immunocytological reaction was controlled. The first oxytocin-neurophysin neurons are seen as early as the 14th week of gestation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222635
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  • 8
    Electronic Resource
    Electronic Resource
    Abstracts of papers deposited at VINITI (1979)
    Springer
    Journal of engineering physics and thermophysics 36 (1979), S. 731-747 
    Details
    ISSN: 1573-871X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01086674
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructural localization of immunoreactive corticotropin, β-lipotropin, α- and β-endorphin in Cells of the human fetal anterior pituitary (1979)
    Springer
    Cell & tissue research 204 (1979), S. 37-51 
    Details
    ISSN: 1432-0878
    Keywords: Corticotropin ; Opioid peptides ; Anterior pituitary ; Human fetus ; Electron microscopic immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cells immunoreactive with anti-α-(17–39) ACTH, β-(1–24) corticotropin, β-LPH, α- and β-EP were identified in the human fetal anterior pituitary at the ultrastructural level using the peroxidase-antiperoxidase complex method on ultrathin sections. Only one definite cell type was revealed by all these antisera. All granules of each individual immunostained cell reacted regardless of the antiserum used. The immunostained cells occurred in groups and were sometimes located in the wall of the follicle-like structures commonly observed in the fetal anterior pituitary. The cells revealed two main aspects: 1) The largest elements were rich in organelles, and their numerous secretory granules showed significant variations in size (250–500 nm in diameter), electron density of their content and stain-deposit intensity. The ergastoplasm, consisting of irregular tubules, was poorly developed. In the vicinity of the conspicuous Golgi apparatus, organelles related to the GERL complex were commonly observed. Multivesicular bodies were frequent. Some of these cells showed bundles of microfilaments (60 nm in thickness). 2) The smaller cells had an electron-lucent hyaloplasm with sparse organelles; they contained fewer granules and never showed microfilaments. The immunocytological results are consistent with the synthesis of a molecule similar to pro-opiocortin by this type of endocrine cell in human fetuses. Morphological evidence for the maturation process of this precursor and for the secretory activity of these cells and its possible regulation is presented and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235163
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  • 10
    Electronic Resource
    Electronic Resource
    Immunocytological localization of LH, FSH, TSH and their subunits in the pituitary of normal and anencephalic human fetuses (1978)
    Springer
    Cell & tissue research 191 (1978), S. 249-265 
    Details
    ISSN: 1432-0878
    Keywords: LH, FSH, TSH ; Human fetus ; Anencephaly ; Immunocytology ; Fetal pituitary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunostaining with antisera to oLH, hCG, hLH, pLHβ, hFSH, hFSHβ, hTSHα and bTSH was used to delineate the gonadotropic and thyrotropic cells of the human fetal anterior pituitary. Hypophyses from 29 normal fetuses, 3 newborn infants, and 5 totally ancencephalic fetuses were used. Several controls to check for the specificity of the immunocytological reaction were made. In normal fetuses, observations showed that: 1) the α subunit was detected from the eighth week and throughout gestation without sex differences; 2) intact LH was detected during the third month, however, age and sex differences were observed during the fourth and fifth months; 3) intact FSH was detected in female fetuses from the beginning of the fourth month, a sex difference was observed; 4) LH and FSH were detected in the same cells; 5) the thyrotropic cells were detectable from 15 weeks of gestation and their number increased during gestation without sex difference; 6) at birth the gonadotropic cells were scarce and were located in the ventromedian zone of the anterior pituitary, while the thyrotropic cells remained numerous and were located in the dorsomedian zone. In anencephalic fetuses: 1) the α subunit existed at each stage studied; 2) the reaction induced by anti-pLHβ and anti-hFSHβ sera was always very weak regardless of sex or age; 3) the thyrotropic cells were more numerous in comparison to the gonadotropic cells. These data are discussed in terms of the relationship of the hypophysiotropic hypothalamic factors to the appearance and evolution of the glycoprotein hormones and their subunits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222423
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