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  • Bone  (13)
  • Aspidin
  • Collagen
  • transformation
  • Springer  (22)
  • American Association for the Advancement of Science
  • American Physical Society
  • Annual Reviews
  • International Union of Crystallography
  • 1975-1979  (14)
  • 1965-1969  (6)
  • 1955-1959  (2)
  • 1945-1949
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  • Springer  (22)
  • American Association for the Advancement of Science
  • American Physical Society
  • Annual Reviews
  • International Union of Crystallography
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Are mitochondria directly involved in biological mineralisation? (1969)
    Springer
    Calcified tissue international 3 (1969), S. 103-105 
    Details
    ISSN: 1432-0827
    Keywords: Mitochondrion ; Calcium ; Excretion ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058652
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation of osteoclasts by velocity sedimentation at unit gravity (1977)
    Springer
    Calcified tissue international 22 (1977), S. 303-313 
    Details
    ISSN: 1432-0827
    Keywords: Osteoclasts ; Sedimentation ; Isolation ; Cells ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract A method is presented for separating osteoclasts from the heterogeneous population of bone and marrow cells. Cell suspensions were prepared from femora of young rabbits by mechanical dispersion. The starting cell suspension typically contained only 1.0%±0.5 osteoclasts. Following an initial 45 min of unit gravity sedimentation in a lucite chamber osteoclasts were primarily distributed in fractions 2–5. A second 45-min sedimentation of these pooled fractions yielded cell suspensions containing greater than 30% osteoclasts (as much as a 50-fold increase over starting percentages). Linear scan analysis, however, revealed that osteoclasts accounted for 73.14%±0.58 of the cell colume. Subsequent in vitro experiments demonstrated linear incorporation of3H-leucine into TCA precipitable protein for cells comprising the osteoclast fraction. Concomitant radiautographs revealed radioactive label in isolated osteoclasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010369
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  • 3
    Electronic Resource
    Electronic Resource
    A macromolecular inhibitor of in vitro calcification of tendon matrix (1978)
    Springer
    Calcified tissue international 25 (1978), S. 161-168 
    Details
    ISSN: 1432-0827
    Keywords: Tendon ; Calcification ; Collagen ; Inhibitors ; Proteoglycans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Bovine and human tendon tissue do not induce calcification in vitro. However, extraction of those tissues with 3% Na2HPO4 converts them to calcifiable matrices. The supernatant fraction derived from the extraction contains a nondialyzable, perchloric acid soluble component that inhibits calcification of the extracted matrix. This inhibitory substance is characterized by a molecular weight in the range of 85,000–100,000. Exposure to pronase or hyaluronidase did not alter the inhibitory potency but did render the inhibitor dialyzable. Commercial sources of hyaluronic acid, chondroitin-6-sulfate, chrondroitin-4-sulfate, dermatan sulfate, heparin and lysozyme did not inhibit calcification of the extracted matrix. Phosvitin, a phosphoglycoprotein is a potent inhibitor. Although phosvitin and the tendon extract also inhibit calcification of previously calcified matrix, they have no detectable effect on the rate of decalcification. We conclude that the mechanism of inhibition is characterized by a degree of specificity and that phosvitin and a macromolecular component of tendon tissue blocks conversion of an intermediate matrix-bound CaP complex to crystalline apatite. It seems reasonable that the tendon inhibitor could function in situ and possibly in vivo to control calcification of tendon tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010764
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  • 4
    Electronic Resource
    Electronic Resource
    Strain related electrical potentials recorded in vitro and in vivo (1977)
    Springer
    Calcified tissue international 22 (1977), S. 315-327 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Bioelectricity ; Strain ; Locomotion ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Using wet dead specimens it was possible to show that the size and form of strain-related electrical potentials on the surface of sheep radii were related both to the amount of strain, and the strain rate, over the range of these recorded during locomotion. Using the same electrode and amplifier system in vivo changes in surface strain and surface charge were recorded from the radius of three sheep during locomotion. During slow locomotion electrical changes were negligible. At medium speed they were most variable, and profoundly influenced by small alterations in the timing and pattern of strain change. When locomotion was fast the electrical waveform reflected fairly faithfully the changes in strain on the bone surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010370
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of fluoride on in vitro calcification of tendon matrix (1978)
    Springer
    Calcified tissue international 26 (1978), S. 51-59 
    Details
    ISSN: 1432-0827
    Keywords: Collagen ; Calcification ; Fluoroapatite ; Nucleation ; Inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Ca2+ and Pi uptake induced in vitro by a collagenous matrix derived from bovine tendon is inhibited by 1×10−6 to 2×10−5 M NaF and stimulated by 2×10−5 to 2×10−3 M NaF. Fluoride uptake occurs only over the latter concentrtion range. The uptake of Ca2+, Pi, and F−1 progresses toward a limiting extent at which the molar Ca/P and Ca/F values are 1.6 to 1.7 and 4.5 to 5.7, respectively. Although the matrix-bound mineral, previously formed in the absence of NaF, readily undergoes dissolution when exposed to a Ca2+- and P-free medium of pH〈7.4, the bound mineral phase formed in the presence of NaF does not. We conclude that fluoroapatite is the primary matrix-bound mineral. The uptake of fluoride, Ca2+. and Pi by both uncalcified and previously calcified matrices is inhibited by methylenediphosphonate and by phosphonoacetate as is calcification in the absence of NaF. Kinetic studies indicate that formation of a CaP complex precedes the uptake of F−1 and suggest that F−1 and OH−1 compete for interation with the CaP complex during the calcification process. We concluded that fluoroapatite formation induced by the collagenous matrix occurs by a multistep pathway comparable to that proposed previously for hydroxyapatite formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013234
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  • 6
    Electronic Resource
    Electronic Resource
    An ultrastructural study of the role of calcification nodules in the mineralization of woven bone (1979)
    Springer
    Calcified tissue international 27 (1979), S. 57-64 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Bone formation ; Calcification ; Calcification nodule ; EM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Osteolathyrism has been used as an experimental model for the study of calcification nodules during the mineralization process. Periosteal exostoses developing in osteolathyrism characteristically have spherical basophilic structures (calcification nodules) in the vicinity of developing bone spicules. In thin sections, the nodules were seen scattered between collagen fibers in the intercellular matrix. Collagen fibers did not appear to be present within the nodules but sometimes were packed just outside them. Matrix vesicles were also present in areas of early mineralization. After EDTA decalcification, the majority of the nodules consisted of a fine granular material surrounded by an electron-dense peripheral zone. The peripheral dense zone was occasionally incomplete in small nodules in areas of early mineralization. An electron-dense central area could be observed in the center of the nodules. Evidence has been presented indicating that the calcification nodules arise from smaller mineralization foci, presumably matrix vesicles. The calcification nodules enlarge to approximately 1.0 µm in size, at which point development is slowed or halted allowing the formation of the peripheral dense zone. Although coalescence of nodules was observed, this was more a random event. The further mineralization of the trabeculae was achieved by the calcification of the collagen fibers. The mineralized trabeculae reflected this pattern of nodular and collagenous calcification. It is suggested that this pattern of calcification is characteristic of rapidly developing woven bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441162
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  • 7
    Electronic Resource
    Electronic Resource
    Bone maturation in the vitamin D, phosphate deficient rat and the response to acid loading (1979)
    Springer
    Calcified tissue international 27 (1979), S. 233-237 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Vitamin D ; Acidosis ; Phosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Vitamin D and phosphate deficiency were produced in rats in order (a) to evaluate the degree of bone mineral and matrix maturation using a bromoform/toluene density gradient technique; and (b) to compare the aforementioned bone maturational changes due to vitamin D and phosphate deprivation to those produced with superimposed severe acidosis. Rats were fed a diet deficient in vitamin D and phosphorus (0.2%) from 3 weeks through 7 weeks of age. To examine the additional contribution of dietary calcium, we gave one-half of the animals either a low (0.06%) or high (1.3%) calcium diet. Following the 4 weeks of vitamin D deficiency, one-half of each group was given 1.8% NH4Cl in the drinking water for 4 succeeding days to induce an acute, severe acidosis. The degree of bone maturation was quantitated via bromoformtoulene density gradient fractionation; total mineral and hydroxyproline (collagen) levels were quantitated as well. The vitamin D-deficient rats deprived of adequate dietary phosphate responded by conserving phosphorus, and as a consequence total bone phosphorus levels were maintained within that level for control rats. This conservation was independent of calcium intake but was extremely sensitive to acute acid loading, where a significant reduction in total bone phosphorus was noted. The bone maturational profile obtained from the vitamin D-phosphate deficient rats, however, revealed a significant accumulation of less mature or dense bone collagen and mineral with a corresponding decrease in the most mature or dense moieties. In contrast to the reduction of the total bone phosphorus content by acute acidosis, the skeletal collagen-mineral maturational profile was not significantly affected by the short-term systemic acidosis. The observed retardations in the bone collagen and mineral maturation of the vitamin D-deficient, phosphate-deprived state provide an additional observation which may well relate to the progressive osteopenia documented in states of chronic, mild acidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441191
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  • 8
    Electronic Resource
    Electronic Resource
    Surface area of dental enamel, bone, and hydroxyapatite: Chemisorption from solution (1978)
    Springer
    Calcified tissue international 26 (1978), S. 139-142 
    Details
    ISSN: 1432-0827
    Keywords: Chemisorption ; Surface area ; Hydroxyapatite ; Bone ; Enamel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The surface areas of three different samples of hydroxyapatite, samples of deproteinized bone, and samples of whole and deproteinized enamel were determined by adsorption of an adduct (the diglycidyl ether of bisphenol A with N-phenylglycine) from methylene chloride solution. In all cases, the surface areas of these samples agree well with those obtained by the BET (N2) method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013248
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of high dietary strontium levels on bone and egg shell calcium and strontium (1969)
    Springer
    Calcified tissue international 4 (1969), S. 180-184 
    Details
    ISSN: 1432-0827
    Keywords: Strontium ; Calcium ; Bone ; Shell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Des poules ont été nourries avec une alimentation riche en strontium stable. Des concentrations de strontium de 3000 p.p. m. à 50000 p.p.m. montre une augmentation nette en strontium du tibia, alors que le contenu en calcium n'est pas modifié. Les concentrations en calcium sérique diminue, lorsque le strontium alimentaire augmente. Le calcium des coquilles d'oeufs diminue progressivement avec l'augmentation du strontium alimentaire, alors que le contenu en strontium des coquilles présente une augmentation correspondante. Des analyses de diffraction par rayons X des os et des coquilles ne permettent pas de déterminer sous quelle forme le strontium est déposé.
    Abstract: Zusammenfassung Die Resultate einer Verfütterung von hohen stabilen Strontiumdosen an Hühnern werden erläutert. Strontiumzusätze zur Nahrung in der Höhe von 3000–50000 p.p.m. führten zu einer signifikanten Zunahme des Strontiumgehaltes der Tibia und verursachten keine wesentlichen Änderungen des Calciumgehaltes. Die Calciumkonzentration im Plasma verminderte sich, wenn der Nahrung ansteigende Strontiummengen zugegeben wurden. Mit zunehmendem Strontiumzusatz zur Nahrung zeigte der Calciumgehalt der Eischale eine fortlaufende Abnahme, während sich der Strontiumgehalt entsprechend erhöhte. Durch Röntgendiffraktionsanalysen der stark Strontium-haltigen Knochen und Eischalen konnte nicht festgestellt werden, in welcher Form das Strontium abgelagert wurde.
    Notes: Abstract The results of feeding high dietary levels of stable strontium to hens are reported. Dietary levels of strontium from 3,000 p.p.m. to 50,000 p.p.m. showed a significant increase in strontium content of the tibia bone and essentially no change in the calcium content. Plasma calcium concentration was shown to decrease with increasing dietary strontium treatment. Egg shell calcium showed a progressive decrease with increasing dietary strontium treatment, whereas the strontium content has a corresponding increase. X-ray diffraction analyses of bones and shells containing large amounts of strontium were unsuccessful in evaluating the from in which strontium was deposited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279119
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  • 10
    Electronic Resource
    Electronic Resource
    Determination of45Calcium and14Carbon ascorbic acid in bone using a liquid scintillation system (1969)
    Springer
    Calcified tissue international 4 (1969), S. 202-209 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Radiocalcium ; Ascorbic acid ; Scintillimetry ; Radiocarbon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Les auteurs on décrit des méthodes pour la détermination de45Ca plus L-1-14C acide asorbique dans les os d'animaux aprés administration des deux isotopes. Calcium et acide asorbique ont été extraits totalement par l'acide trichloracétique a 6% des os a l'état frais en évitant de détruire l'acide asorbique. La détermination chimique du calcium et de l'acide asorbique selon les méthodes classique a été faite dans des portions de l'échantillon. La détermination de la radioactivité du calcium et de l'acide asorbique a été faite ensuite dans des portions du même échantillon. Du Triton a servi pour le scintillant liquide dans le compteur de scintillation liquide. Un procédé de détermination des deux isotopes dans le meme echantillon a été décrit. Différents critéres on été appliques a chacque étape afin d'établir la validité et les limites d'application de la méthode.
    Abstract: Zusammenfassung Eine Methode ist beschrieben, die die quantitative und radioaktive Bestimmung von45Ca und L-[-L14C] Ascorbinsäure in Knochen von Tieren, denen die beiden Isotopen verabreicht worden sind, erlaubt. Calcium und Ascorbinsäure werden quantitativ mit 6% Trichloressigsäure ausgezogen, wobei die Ascorbinsäure erhalten bleibt. Quantitative Analysen für Calcium und Ascorbinsäure werden nach bekannten Methoden in einem Teil des Extraktes bestimmt und die Bestimmung der Radioaktivität in einem anderen Anteil mit Hilfe eines Flüssigkeits-Szintillations-Zählers durchgeführt. Dem flüssigen Szintillanten wird Triton zugesetzt. Diese Versuchsanordnung ermöglicht außerdem die gleichzeitige Bestimmung der beiden Isotopen im Knochen-Extrakt. Die Methode wurde sorgfältig auf ihre Verwendbarkeit ausgewertet.
    Notes: Abstract Methods were developed for the determination of45Ca plus L-[1-14C] asorbic acid in bones of animals following administration of both isotopes. Asorbic acid and calcium were extracted quantitatively with 6% trichloracetic acid from fresh bone under such mild conditions that asorbic acid was not destroyed. The chemical determinations of calcium and ascorbic acid according to standard procedures were performed in aliquots of the same extract. The determination of the radioactivity of calcium and ascorbic acid were then carried out in aliquots of the same extract. A Triton-containing liquid scintillation fluid was employed for the radioassay of45Ca and L-[1-14C] ascorbic acid in the liquid scintillation spectrometer. A procedure allowing the determination of both isotopes in the same extract is described. A number of criteria were applied to each step, in order to determine the validity and limitations of the procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279123
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