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  • 1975-1979  (2)
  • 1970-1974  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 39 (1977), S. 317-337 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract This paper uses the Gompertzian model for the growth of a cancer cell population subject to losses due to the action of cycle nonspecific therapy for the determination of a chemotherapy program obtained from optimal control theory. Application of the analysis to control of the bone cancer IgG multiple myeloma is presented. The program obtained from optimal control theory is compared with clinical results.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 6 (1970), S. 299-319 
    ISSN: 1573-2878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract A complete set of necessary and sufficient conditions for selecting optimal endpoints for extremals obtained from the variational Bolza problem in control notation has been developed. The method used to obtain these conditions is based on a seldom used concept of performing a dichotomy on the general optimization problem. With this concept, the problem of Bolza is decomposed into two problems, the first of which involves the selection of optimal paths with the endpoints considered fixed. The second problem involves the selection of optimal endpoints with the paths between the endpoints taken to be stationary curves. The convenience of the dichotomy in deriving the necessary and sufficient conditions for endpoints lies in its simplicity and elementary character; well-known necessary and sufficient conditions from the theory of ordinary maxima and minima are used. An endpoint necessary condition is first obtained which is simply the well-known transversality condition. An additional condition is then developed which, together with the transversality condition, leads to a set of necessary and sufficient conditions for a given extremal to be locally optimal with respect to endpoint variations. While the second condition presented is akin to the classical focal-point condition, the result is new in form and is directly applicable to the optimal control problem. In addition, it is relatively simple to apply and is easy to implement numerically when an analytical solution is not possible. It should be useful in situations where the transversality conditions yield more than one choice for an optimal endpoint. An analytic solution for a simple geodetics problem is presented to illustrate the theory. A discussion of numerical implementation of the sufficiency conditions and its application to an orbit transfer example is also included.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 1970-10-01
    Print ISSN: 0022-3239
    Electronic ISSN: 1573-2878
    Topics: Mathematics
    Published by Springer
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  • 4
    Publication Date: 1977-10-01
    Print ISSN: 0304-3800
    Electronic ISSN: 1872-7026
    Topics: Biology
    Published by Elsevier
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