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Pyridine nucleotide metabolism in imaginal discs of Drosophila melanogaster (1976)

Keyes, Ted W. ; Olivera, Baldomero M. ; Stewart, D. J. ; [et al.]

Springer

Biochemical genetics 14 (1976), S. 197-207

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ISSN: 1573-4927

Keywords: pyridine nucleotide metabolism ; imaginal discs ; NAD turnover ; ecdysterone

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract The pyridine nucleotide metabolism of imaginal discs of Drosophila melanogaster has been studied in vitro by incubating discs with labeled nicotinic acid in the presence and absence of ecdysterone. The major labeled compounds found within the discs are NAD, NADP, and nicotinic acid. There is preferential uptake of nicotinamide over nicotinic acid, although the Priess-Handler pathway is used exclusively. The presence of ecdysterone produces a small increase in the NADP/NAD ratio, and an increase in NAD synthesis, probably to compensate for increased NAD turnover.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00484760

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