ISSN:
1573-1561
Keywords:
Rat
;
Rattus norvegicus sp.
;
odorants
;
stress
;
behavior
;
open field
;
corticosterone
;
fox dropping
;
ketone
;
sulfur
;
compounds
;
tans
;
mercaptoketones
;
repellent
;
structure-activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The stress for 12 sulfur-containing synthetized volatiles was evaluated in male Wistar rats and compared to that for fox-dropping extract concentrate. Stress behavior was analyzed by quantifying various stress responses in a standard open field and measuring the increase in plasma corticosterone concentration. Nine compounds induced stress—a dihydrothiazole, two cyclic polysulfides, five mercaptoketones, and a mercaptan. For the mercaptoketones, the following structure-activity relationships were observed. Size can vary considerably; the mercapto group can be either alpha or beta and either secondary or tertiary. The keto group is not essential, since a structurally related mercaptan remains active. The mercapto group is essential for activity in mercaptoketones, since conversion to a methyl sulfide resulted in a neutral response. This type of odorant could function as an allomone and may have potential in rat control as an area repellent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00987509
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