ISSN:
1573-9171
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Conclusions 1. The acylation of 4,6-diamino-2-mercaptopyrimidine with carboxylic acid chlorides in the presence of an organic base proceeds at all of the nucleophilic centers: the S atom, the ring N atom, or the amino group. The direction of the acylation depends on the temperature, the nature of the reactants, and the order of their addition. 2. Members of all three types of monoacylated derivatives were obtained, and specifically the 2-acylthio-4,6-diaminopyridines, the 1-acyl-4,6-diamino-1,2-dihydro-2-pyrimidinethiones, and the 6-amino-4-acylamide-1H(3H)-dihydro-2-pyrimidinethiones. 3. The acylation of the 4,6-diamino-2-mercaptopyrimidine salts gives a mixture of the S- and N1-acylated derivatives, whose composition is affected by the nature of the cation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00951232
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