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  • 1980-1984  (9)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Increased gastro-intestinal absorption of hexobarbital by hydrophilization (1980)
    Springer
    Pharmacy world & science 2 (1980), S. 541-547 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper reports a comparative evaluation of thein vivo andin vitro availability of pure and hydrophilised hexobarbital from capsules. Hydrophilization of the poorly soluble hydrophobic drug was performed by coating the powder particles with hydrophilic methylcellulose. Liquid penetration into plugs of the treated powder, disintegration times andin vitro release rates became independent of the liquid wetting potency and were extremely fast compared with the pure drug. A bioavailability study in eight healthy volunteers showed a strongly increased extent and rate of absorption of the treated drug compared with the pure drug. The absorption rate of the hydrophilised free acid of hexobarbital was almost as rapid as that of the sodium salt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02273084
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  • 2
    Electronic Resource
    Electronic Resource
    Tabletteren en tabletten (1980)
    Springer
    Pharmacy world & science 2 (1980), S. 993-1000 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02273248
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  • 3
    Electronic Resource
    Electronic Resource
    Boekbesprekingen (1981)
    Springer
    Pharmacy world & science 3 (1981), S. 627-634 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02193232
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  • 4
    Electronic Resource
    Electronic Resource
    Novel techniques for determination of antibacterial activity of silver sulfanilamides (1983)
    Springer
    Pharmacy world & science 5 (1983), S. 61-64 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract By means of suspension techniques,mic's of ten silver sulfanilamides against fifty-six different strains of bacteria were determined. The only two bacteria which were sensitive wereStreptococcus pyogenes andEscherichia coli. The local application of these drugs in burn patients only reduces colonization. The cream base is probably also involved in the anticolonization effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960077
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  • 5
    Electronic Resource
    Electronic Resource
    Oral controlled release dosage forms. A review (1984)
    Springer
    Pharmacy world & science 6 (1984), S. 57-67 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract When a drug meets the criteria which make incorporation into a controlled release dosage form rational, a proper dosage form has to be selected. Oral controlled release products, available on the Dutch market, are referred to in discussing the various methods used to control drug release by galenical means in order to achieve a prolonged therapeutic effect. The effects of some physiological variables of the alimentary tract on drug delivery from the various dosage forms, especially with regard to formulation and design, are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953956
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of particle size of disintegrants on the disintegration of tablets (1981)
    Springer
    Pharmacy world & science 3 (1981), S. 1048-1051 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effect has been studied of particle size of disintegrants on the disintegration time of tablets, compressed without a lubricant and after mixing the ingredients with magnesium stearate, respectively. The results show for the tablets containing a slightly swelling disintegrant, like potato and rice starch, a decreasing negative effect of mixing with magnesium stearate on the disintegration time of the tablets with decreasing particle size of disintegrant. Only a slight effect of particle size and of mixing time with magnesium stearate on the disintegration of the tablets is found for the tablets containing a strongly swelling disintegrant, like sodium starch glycolate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02193321
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  • 7
    Electronic Resource
    Electronic Resource
    Studies on different dissolution models (1982)
    Springer
    Pharmacy world & science 4 (1982), S. 191-196 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A comparative study of the action of erosion on non disintegrating theophylline tablets was performed in the threeusp xx dissolution models, the rotating basket, the paddle and the modified disintegration apparatus, as well as in a new (sandwich) model. The results show erosion to be dependent on the mechanical strength of the tablets and to be promoted by the phenomenon of softening of the tablets during the process of dissolution. A considerable and moderate erosion was found for ‘soft’ tablets in the rotating basket and disintegration apparatus, respectively, whereas no or only slight erosion was observed in the paddle and sandwich models. The phenomenon of dissolution intensified erosion and erosion intensified dissolution is shown to affect the description of the release profiles. The dissolution profiles of the ‘hard’ tablets in the models preferred to be described by the square root equation, whereas the profiles of the ‘soft’ tablets in the case of erosion showed a tendency to a better fit with the cube root of mass versus time relation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959138
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  • 8
    Electronic Resource
    Electronic Resource
    Improvement by super disintegrants of the properties of tablets containing lactose, prepared by wet granulation (1983)
    Springer
    Pharmacy world & science 5 (1983), S. 165-171 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The crushing strength, disintegration and dissolution properties of tablets, made by wet granulation with lactose as filler, gelatin as binder, potato starch as disintegrant and magnesium stearate as lubricant can be markedly improved when the potato starch (20%) is replaced by a much lower concentration (4%) of an insoluble super disintegrant, such as sodium starch glycolate (Primojel®) or crospovidone (Polyplasdone® Xl). The incorporation of partially water soluble super disintegrants such as low-substituted sodium carboxymethylcellulose (Nymcel®,Zsd 16), causing a viscous barrier in the tablets when containing water, is shown to be deleterious for both tablet disintegration and drug release. In contrast to potato starch, the position of the super disintegrants (intragranular, extragranular or equally distributed) had hardly any effect on the tablet properties. The improved properties of the tablets containing insoluble super disintegrants, when compared to tablets with potato starch, are the result of the use of a much lower concentration of disintegrant, but especially of the difference in effect of magnesium stearate on the disintegration capacity of the slightly swelling potato starch and the strongly swelling super disintegrants, respectively. The latter cause, even in the presence of the liquid penetration inhibiting hydrophobic magnesium stearate, a chain reaction of opening of the tablet, starting at the outside and resulting in a fast disintegration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01961475
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  • 9
    Electronic Resource
    Electronic Resource
    Development and optimization of pharmaceutical formulations using a simplex lattice design (1984)
    Springer
    Pharmacy world & science 6 (1984), S. 185-194 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The composition of pharmaceutical formulations is often subject to trial and error. This approach is time consuming and unreliable in finding the best formulation. Optimization by means of an experimental design might be helpful in shortening experimenting time. Such a design with the concomitant mathematical models, reveals effects and interactions of the variables. The independent variables are the different compositions of the mixtures of the chosen ingredients [drug(s) and excipients]. The dependent variables are the properties (responses) of the formulation. When all responses of interest have been expressed in models that describe the response as a function of the composition of the mixture, the models can be combined graphically or mathematically to find a composition satisfying all demands. In this paper an introduction to the use of mixture designs will be given by means of a theoretical part and an example: optimizing a tablet formulation consisting of excipients only.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01999941
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