ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A model of the randomly coiling form of poly(rU) based on minimum-energy conformers of UpU is described. The blend of conformers is chosen to fit the C—C rotational populations derived in nmr studies of UpU and poly(rU) and to match the experimental unperturbed dimensions of the poly(rU) chain. In addition, estimates of loop closure based on the model are comparable to the sizes of loops most frequently seen in model oligonucleotides. Approximately 60% of the conformers constituting the model are characterized by stacked, extended C2′-endo ω′ωψ = tg-g+ rotations. The remainder of the chain is described by equal numbers of C3′-endo A (ω′ωψ = g-g-g+) and Watson-Crick (ω′ωψ = g-tt) helical arrangements.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.360210612
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