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  • Neurohypophysis  (2)
  • 1980-1984  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Effects of tunicamycin on the hypothalamo-neurohypophysial system of the rat (1981)
    Springer
    Cell & tissue research 217 (1981), S. 199-210 
    Details
    ISSN: 1432-0878
    Keywords: Hypothalamus ; Neurohypophysis ; Neurophysin ; Secretion ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Intracisternal injections of tunicamycin, an inhibitor of glycosylation, decreased the incorporation of [35S]cysteine into the neurophysins in the rat neurohypophysis. Histochemical and immunocytochemical studies showed that there was no concomitant decrease in the amount of secretory product in the perikarya of the hypothalamo-neurohypophysial neurones. Indeed there was an increase, although this was not associated with neurosecretory granules as judged electron-microscopically. Tunicamycin led to the formation of socalled “colloid droplets” which were immunopositive and of which the ultrastructural correlates appeared to be product-filled dilatations of the rough endoplasmic reticulum. The observations are interpreted to suggest that glycosylation plays a rôle in the packaging of secretory material in the hypothalamo-neurohypophysial system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233838
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of small doses of colchicine on the components of the hypothalamo-neurohypophysial system of the rat (1981)
    Springer
    Cell & tissue research 220 (1981), S. 809-827 
    Details
    ISSN: 1432-0878
    Keywords: Neurohypophysis ; Neurophysins ; Intra-axonal transport ; Immunocytochemistry ; Colchicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Small doses (3.5 μg and 7 μg) of colchicine injected intracisternally caused an interruption of transport of secretory material from the supraoptic and paraventricular nuclei of the hypothalamus to the neural lobe of the pituitary gland. Transport was assessed by direct measurement of the incorporation of [35S] cysteine into neurophysins, by radioimmunoassay of accumulated material in discrete areas of the system and by immunocytochemistry. The larger dose (7 μg) switched off transport completely during the first 24 h but the system began to recover within three to four days. Colchicine had little, if any, effect on synthesis; comparison of the relationships of the apparent amounts of immunoreactive neurophysins and immunoreactive hormones in the arrested product led to the conclusion that processing of the hormone precursors continues within the secretory granules which accumulated in the perikarya.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210464
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    Paper (German National Licenses)
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