Publication Date:
1981-08-07
Description:
Hypoxia was produced in isolated, hemoglobin-free, perfused rat liver by reducing the flow rate of oxygen-carrying fluid entering the organ. The procedure caused anoxia in centrilobular regions. In these anoxic areas, structural derangements developed rapidly, characterized by bleb-like protrusions of hepatocyte plasma membrane through fenestrations in the sinusoidal endothelium. Periportal tissue remained normoxic and was completely spared. Cellular injury resulting from localized anoxia may play an important role in the pathogenesis of centrilobular liver disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemasters, J J -- Ji, S -- Thurman, R G -- AA-00033/AA/NIAAA NIH HHS/ -- AA-03624/AA/NIAAA NIH HHS/ -- AA-04853/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):661-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256265" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anoxia/*complications
;
Cell Membrane/pathology
;
Female
;
Liver/*blood supply
;
Liver Diseases/*etiology/pathology
;
NAD/metabolism
;
NADP/metabolism
;
Oxidation-Reduction
;
Rats
;
Regional Blood Flow
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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