Publication Date:
1984-04-06
Description:
Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade. This work has permitted fundamental insights into how binding of neurotransmitters to their receptors excites or inhibits neuronal firing or changes cellular metabolism. The recognition of receptor subtypes has suggested subtle ways for neurotransmitters to modulate neuronal functioning. Finally, the ability to measure receptor sites in simple test tube systems and to distinguish readily between agonists and antagonists has provided useful probes for drug discovery programs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):22-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322304" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*metabolism/physiology
;
Brain Chemistry
;
Calcium Channel Blockers/metabolism
;
Cerebellum/metabolism
;
Humans
;
Rabbits
;
Rats
;
Receptors, Adrenergic/metabolism
;
Receptors, Catecholamine
;
Receptors, Cell Surface/metabolism
;
Receptors, Dopamine/metabolism
;
Receptors, Drug/analysis/*metabolism/physiology
;
Receptors, GABA-A
;
Receptors, Neurotransmitter/analysis/*metabolism/physiology
;
Receptors, Opioid/metabolism
;
Receptors, Purinergic
;
Receptors, Serotonin/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink