Publication Date:
1984-02-17
Description:
Intracellular recordings were obtained in the vitro slice preparation from neurons of lateral and mesial temporal cortex removed from human epileptics suffering from intractable temporal lobe seizures. Spontaneous rhythmic synaptic events, which were capable of triggering action potential discharge, were observed in many neurons, particularly in mesial tissue slices. Such activity may reflect the epileptogenic capacity of this human cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartzkroin, P A -- Knowles, W D -- NS 00413/NS/NINDS NIH HHS/ -- NS 17111/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):709-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695179" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials/drug effects
;
Cerebral Cortex/*physiopathology
;
Epilepsy/*physiopathology
;
Hippocampus/physiopathology
;
Humans
;
Neurons/drug effects/*physiology
;
Seizures/physiopathology
;
Temporal Lobe/physiopathology
;
Tetrodotoxin/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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