Publication Date:
1980-04-25
Description:
Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stuart, R K -- Hamilton, J A -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):402-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245446" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Division/drug effects
;
Cells, Cultured
;
*Colony-Forming Units Assay
;
Colony-Stimulating Factors/pharmacology
;
Dose-Response Relationship, Drug
;
Hematopoietic Stem Cells/*drug effects
;
Macrophages/physiology
;
Mice
;
Monocytes/physiology
;
Phorbol Esters/pharmacology
;
Phorbols/*pharmacology
;
Receptors, Cell Surface/drug effects
;
Structure-Activity Relationship
;
Tetradecanoylphorbol Acetate/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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