Publication Date:
1982-04-23
Description:
Lesions to the entorhinal afferent of the hippocampus in rats caused marked changes in calcium transport into mitochondria. Pyruvate-supported calcium transport into mitochondria from the denervated hippocampus was decreased to a larger extent than succinate-supported transport, and adenosine triphosphate-supported transport was not significantly modified. Although cytochrome oxidase and succinate dehydrogenase activities were not significantly changed by entorhinal lesions, pyruvate flux through pyruvate dehydrogenase was significantly decreased, and this effect was correlated with changes in pyruvate-supported calcium transport. The active portion of pyruvate dehydrogenase decreased, whereas total pyruvate dehydrogenase was not modified. These data suggest that denervation might initiate dendritic atrophy and subsequent growth responses by modifying calcium regulation through a change in the phosphorylation of pyruvate dehydrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baudry, M -- Fuchs, J -- Kessler, M -- Arst, D -- Lynch, G -- AG00538/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071588" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/metabolism
;
Animals
;
Calcium/*metabolism
;
Denervation
;
Hippocampus/*metabolism/ultrastructure
;
Mitochondria/*metabolism
;
Nerve Degeneration
;
*Neuronal Plasticity
;
Phosphoproteins/metabolism
;
Pyruvate Dehydrogenase Complex/*metabolism
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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