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  • 1
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    Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: The synthetic peptide NH2-Tyr-Pro-Phe-Pro-CONH2 (morphiceptin), which is the amide of a fragment of the milk protein beta-casein, has morphinelike activities and is highly specific for morphine (mu) receptors but not for enkephalin (delta) receptors. It is as active as morphine in the guinea pig ileum but much less active in the mouse and rat vas deferens. The discovery of this specific morphine receptor ligand substantiates the hypothesis of multiple opiate receptors. The ligand, which may be of physiological significance since a very similar, or identical, activity can be detected in enzymatic digests of beta-casein, may prove useful for further investigation of the functions of opiate receptor subtypes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, K J -- Lillian, A -- Hazum, E -- Cuatrecasas, P -- Chang, J K -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Caseins/pharmacology ; Dihydromorphine/metabolism ; Endorphins/*pharmacology ; Enkephalins/metabolism ; Guanosine Triphosphate/pharmacology ; Guinea Pigs ; Ileum/drug effects ; Male ; Mice ; Naloxone/metabolism ; Rats ; Receptors, Opioid/*drug effects ; Sodium/pharmacology ; Vas Deferens/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Immunoreactive dynorphin-(1-8) and corticotropin- releasing factor in subpopulation of hypothalamic neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-14
    Description: Immunoreactive corticotropin-releasing factor (CRF) and dynorphin-(I-8) were visualized in rat hypothalamus by immunohistofluorescence with specific antibodies. In brains from colchicine-treated, adrenalectomized rats, neuronal perikarya with immunoreactive CRF were observed in the paraventricular nucleus of the hypothalamus. The CRF occurred together with the dynorphin-(1-8). However, the CRF immunoreactivity occurred only in a subpopulation of the dynorphin-(1-8) immunoreactive cells. These findings suggest that there may be a functional interrelationship of CRF with dynorphin-related opioid peptides and provide further evidence that neurons may contain more than one bioactive substance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, K A -- Weber, E -- Barchas, J D -- Chang, D -- Chang, J K -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6129700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corticotropin-Releasing Hormone/immunology/*metabolism ; Dynorphins ; Endorphins/immunology/*metabolism ; Fluorescent Antibody Technique ; Hypothalamus/cytology/*metabolism ; Neurons/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; Peptide Fragments/metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    On the proper boundary conditions for the thermal entry problem (1980)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 15 (1980), S. 935-942 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620150612
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  • 4
    Electronic Resource
    Electronic Resource
    Some problems of a plate bending hybrid model with shear effect (1982)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 18 (1982), S. 755-764 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A triangular plate bending hybrid element is constructed according to Reissner's principle. It has 9 degrees-of-freedom and the shear effect is included. The C0 formulation of thick plate is directly developed to solve the thin plate by imposing the discrete Kirchhoff constraints. The matching problem for bending and shear in the hybrid model of thick plate is effectively treated by use of the principle of the energy regulation such that the unified analysis of thick and thin plates is realized. Finally, numerical examples are presented.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620180510
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  • 5
    Electronic Resource
    Electronic Resource
    Subdivision of the Bézier curve (1983)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 19 (1983), S. 1227-1233 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Any segment between two points on a Bézier curve is itself a Bézier curve whose Bézier polygon is expressed explicitly in terms of the sides of the Bézier polygon associated with the original curve.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620190809
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  • 6
    Electronic Resource
    Electronic Resource
    A partial-boundary element approach to the elastic torsion problem of a prismatic beam with a cracked rectangular cross-section (1984)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 20 (1984), S. 1745-1749 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Using the partial-boundary element approach, in which only a part of the boundary in problem is discretized, the elastic torsion problem of a prismatic beam of a cracked rectangular cross-section has been solved in this brief paper, together with a numerical example to show the accuracy and versatility of the approach.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620200916
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  • 7
    Electronic Resource
    Electronic Resource
    Optimum design sensitivity based on approximation concepts and dual methods (1984)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 20 (1984), S. 39-75 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An optimum design sensitivity analysis capability is reported which exploits the approximation concepts-dual method formulation of the minimum weight structural sizing problem. An efficient iterative solution technique is used to facilitate determination of sensitivity derivatives for both primal and dual variables. Estimates on the useful range of parameter perturbations, over which the optimum design sensitivity projections can be expected to yield satisfactory revised optimum designs, are also obtained. Numerical results for several example problems will be presented to illustrate the effectiveness of the capability reported.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620200105
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  • 8
    Electronic Resource
    Electronic Resource
    Oscillatory behavior of a gas bubble growing (or collapsing) in viscoelastic liquids (1982)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 28 (1982), S. 1002-1009 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A theoretical study was carried out to achieve a better understanding of the oscillatory behavior of a gas bubble growing (or collapsing) in a viscoelastic liquid, by taking into account both the hydrodynamic and diffusion effects. The Zaremba-DeWitt model was chosen to represent the rheological properties of the suspending medium. The finite difference method was employed to solve the governing system equations.The computational results show that, in the case of very fast diffusion (i.e., constant bubble pressure), the oscillatory behavior of a bubble takes place only when the ratio of the initial pressure difference between the gas bubble and the liquid phase to the elastic modulus of the suspending medium is below a certain critical value. On the other hand, in the case of very slow diffusion, the oscillatory behavior of a bubble persists, regardless of the magnitude of the rheological properties of the suspending medium. Our study indicates further that the diffusivity of a gas has a profound influence on the occurrence of oscillatory behavior, that the elastic property of the suspending medium enhances oscillatory behavior while its viscosity plays the opposite role, and that even a Newtonian medium can give rise to an oscillatory pattern of bubble growth (or collapse), although it dampens out very quickly.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690280616
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  • 9
    Electronic Resource
    Electronic Resource
    Numerical calculation of effectiveness factors for the Michaelis-Menten type kinetics with high thiele moduli (1982)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 28 (1982), S. 1030-1032 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690280621
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  • 10
    Electronic Resource
    Electronic Resource
    A non-Fickian model of packed-bed reactors (1982)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 28 (1982), S. 208-214 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A model for packed-bed reactors with dispersion is derived rigorously via the volume averaging approach. Though it is quantitatively more consistent with experimental data, it requires less computational efforts than the prevalent Fickian model. The adverse effects of dispersion on conversion are demonstrated both numerically and analytically using the new model.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690280207
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