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  • 79.20. −m  (1)
  • plasma levels  (1)
  • 1980-1984  (2)
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  • 1980-1984  (2)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 29 (1982), S. 57-61 
    ISSN: 1432-0630
    Keywords: 79.20. −m ; 61.80. −x ; 71.35. +z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract We present the first experimental results on electron-induced erosion of solid neon. The measurements are interpreted qualitatively within a new model invoking excitation transport by free excitons and their subsequent decay at the surface. The model accounts for the magnitude of the observed yield and the energy dependence. A theoretically predicted decrease in the erosion yield due to doping with a heavier rare gas, in casu argon, has been observed experimentally. The strong influence of very small amounts of different types of impurities makes sample purity a crucial problem in investigations of the erosion of solid rare gases.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 26 (1984), S. 749-752 
    ISSN: 1432-1041
    Keywords: dextropropoxyphene ; pharmacokinetics ; half-life ; 3-compartment model ; steady state prediction ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Data from a previously published single dose study of d-propoxyphene 65 mg given i.v. to 8 healthy subjects have been subjected to non linear regression analysis by a curve-fitting program to test the applicability of a 2- and a 3-compartment open model. Analysis of residuals (difference between observed and computed concentrations) revealed similar systematic deviations in all 8 subjects when the 2-compartment model was used (5–10 h negative residuals, after 13 h positive residuals). In contrast, curve-fit by a 3-compartment model (with two parallel peripheral compartments) was good with no systematic deviations. The data show that a terminal monoexponential decline in d-propoxyphene concentrations cannot be expected until 15–30 h after single dose administration, and that the determination of the corresponding half-life is rather inaccurate. Accordingly, precise steady state level predictions may be difficult to obtain from conventional single dose studies with d-propoxyphene.
    Type of Medium: Electronic Resource
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