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  • 1
    Electronic Resource
    Electronic Resource
    Changes in circulating thyroid hormones during short-term hepatic enzyme induction with carbamazepine (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 453-456 
    Details
    ISSN: 1432-1041
    Keywords: carbamazepine ; thyroid hormones ; antipyrine ; enzyme induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of short-term hepatic enzyme induction with carbamazepine (CBZ) on circulating thyroid hormone concentrations was studied in 10 healthy male subjects. CBZ 400 mg per day was given for 21 days in 6 subjects and for 14 days in a further 4. In the former group the effect of therapy on the pituitary/thyroid axis was also assessed by measuring thyroid stimulating hormone (TSH) response to thyrotrophin-releasing hormone. CBZ therapy resulted in induction of hepatic monooxygenase activity, evidenced by a fall in antipyrine half-life (11.1±0.7 to 7.6±0.7 h; p〈0.001), and a rise in antipyrine clearance (0.72±0.06 to 0.98±0.1 ml min−1 kg−1; p〈0.001). A significant fall in total serum thyroxine (T4) (81.9±2.9 to 75.1±2.9 nmol l−1), and triiodothyronine (T3); (1.59±0.07 to 1.37±0.05 nmol l−1) and free T4 (16.03±0.82 to 14.2±0.8 pmol l−1) was seen after CBZ therapy. (all p〈0.05). No significant change in reverse T3 or thyroid binding globulin occurred. In the 6 subjects studied for 21 days, maximal changes were found following 14 days' treatment. Basal and stimulated TSH remained unaltered. These effects on circulating thyroid hormone concentrations are likely to be secondary to hepatic enzyme induction leading to accelerated nondeiodinative hepatic hormone disposal. The reason for the failure of pituitary TSH secretion to rise in response to the fall in circulating T4 and T3 is unclear but may have implications for chronic treatment with CBZ in epileptic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542140
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    Paper (German National Licenses)
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  • 2
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    Labeled putrescine as a probe in brain tumors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-12
    Description: The polyamine metabolism of transplanted N-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Volkow, N -- Goldman, S S -- Flamm, E S -- Cravioto, H -- Wolf, A P -- Brodie, J D -- NS15638/NS/NINDS NIH HHS/ -- S07RR05399/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):673-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603020" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Brain Neoplasms/*radionuclide imaging ; Glioma/radionuclide imaging ; Kinetics ; Neoplasm Transplantation ; *Putrescine/metabolism ; Rats ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    The soft X-ray spectrum of the Vela supernova remnant (1983)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: An X-ray spectrum of a major fraction of the Vela supernova remnant has been obtained during scanning observations with the low energy proportional counters of the A-2 experiment, flown on HEAO 1. A deconvolution analysis of the data shows that the spectrum exhibits pronounced line emission near 0.6 keV due primarily to oxygen ions. Model fits using the Raymond-Smith hot plasma emission calculations indicate that the spectrum can be well described by a model involving two collisional equilibrium components with temperatures of 2.4 x 10 to the 6th and 1.9 x 10 to the 7th K, respectively. The abundances of oxygen and iron are found to be constrained to lie near their normal cosmic values.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 269; June 1
    Format: text
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    NASA TECHNICAL REPORTS
  • 4
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    Optical observations of the BL Lacertae object PKS 2155-304 and implications regarding the X-ray absorption feature at 600-700 eV (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The interpretation of the PKS 2155-304 identification as a BL Lac object whose X-ray spectrum contains an absorption trough has been hampered by the lack of a reliable redshift for the source. Spectra derived from extensive optical observations of this source imply a redshift of 0.117 + or - 0.002. With knowledge of the redshift, the range of mechanisms which can produce the X-ray trough can be reduced. Attention is given to these alternative mechanisms.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters to the Editor (ISSN 0004-637X); 278; L103-L10
    Format: text
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    NASA TECHNICAL REPORTS
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