Publication Date:
1983-02-25
Description:
Ammonium chloride, a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells. Subsequent removal of ammonium chloride results in the rapid establishment of a persistent infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Canning, W M -- Fields, B N -- AI 13178/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):987-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297010" target="_blank"〉PubMed〈/a〉
Keywords:
Ammonium Chloride/*pharmacology
;
Animals
;
Hydrogen-Ion Concentration
;
L Cells (Cell Line)
;
Lysosomes/physiology
;
Mice
;
Reoviridae/*growth & development
;
Reoviridae Infections/*etiology
;
Virus Replication/*drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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