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  • 1
    Electronic Resource
    Electronic Resource
    Protein-Semisynthese mit Hilfe gemischter Anhydride und Enzyme (1981)
    Springer
    Naturwissenschaften 68 (1981), S. 56-62 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract Proteins play a prominent role in nature and their biosynthesis occurs via stepwise combination of amino acids. One can imitate this method in laboratory or synthesize the polypeptide chain by combining smaller preformed fragments (fragment condensation). Reversible protection of reactive groups and solubility problems arising are the most important features in this regard. Semisynthesis, i.e., coupling of amino acids or peptides to natural material may help to overcome these difficulties. The preparation of hybrid preproinsulin by mixed anhydride synthesis and the conversion of pork insulin to human insulin by enzyme-catalyzed peptide synthesis are two examples of the semisynthesis of proteins. In both cases optimal reaction conditions are essential for maximal yield of the product desired. In spite of the rapid improvement of gene technology, chemical peptide synthesis will retain its value for the preparation of biologically and pharmacologically interesting substances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01047223
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  • 2
    Electronic Resource
    Electronic Resource
    Zum Reaktionsmechanismus von Glutaraldehyd mit Proteinen (1981)
    Springer
    Monatshefte für Chemie 112 (1981), S. 1313-1323 
    Details
    ISSN: 1434-4475
    Keywords: Crosslinking mechanism ; N-Alkyl-1,4-dihydropyridines ; N,N′-Alkyl-1,5-diiminopentanes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The interaction of glutaraldehyde with model aliphatic amines was studied in order to understand the crosslinking reaction of glutaraldehyde with proteins. The reaction in organic solvents gave N-alkyl-1,4-dihydropyridines and N,N′-dialkyl-1,5-diiminopentanes. The isolated products are new or were previously described by us for the first time1. Hydration of the reaction products led to stable N-alkylpiperidines and N,N′-dialkyl-1,5-diaminopentanes. In aqueous solution the reaction depends on thepH: at apH above 7, N-alkyl-1,4-dihydropyridines and at apH below 7, polymers were obtained. For the crosslinking reaction of proteins with glutaraldehyde the following mechanism is proposed: Monomeric glutaraldehyde reacts with the protein to give intermediate N-alkyl-2,6-dihydroxypiperidines. Intramolecular dehydration leads to the corresponding N-alkyl-1,4-dihydropyridines. Condensation of the cyclic monohydrate of glutaraldehyde and N-alkyl-2,6-dihydroxypiperidines gives linear polymeric crosslinks containing α-oxo-N-alkylpiperidine units.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00904683
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  • 3
    Electronic Resource
    Electronic Resource
    Purification of a nuclease from human serum (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 548-550 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The purification procedure for a nuclease from human serum is described. It includes ammonium sulfate precipitation, chromatography on DEAE-Sephadex and on Sephacryl-S 200, and preparative electrophoresis. The enzyme, purified about 2000-fold, is homogeneous in a sodium dodecyl sulfate electrophoretic system, where it has a mol. wt of 78,000. The pH optimum lies around pH 6.5; it is a sugar-nonspecific endonuclease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990041
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  • 4
    Electronic Resource
    Electronic Resource
    Histoincompatibility reactions in the hydrocoral Millepora dichotoma (1983)
    Springer
    Coral reefs 1 (1983), S. 237-241 
    Details
    ISSN: 1432-0975
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Notes: Abstract The xenogeneic- and allogeneic immunological specificity of the hydrocoral Millepora dichotoma has been investigated. Xenogeneic histoicompatibility reactions have been observed between this hydrocoral and a series of species belonging to the Demospongiae and to the Anthozoa (both Hexacorallia and Octocorallia). The xenogeneic histoincompatibility reactions proceed in the following sequence: (a) Species-unspecific sensitization; (b) necrosis formation, which is very likely due to an autolytic process; (c) callus formation, due to an hyperplastic growth of stolons; and (d) formation of a contact barrier in form of a barrier layer or a restored stolonial layer. Allogeneic histoincompatibility reactions are restricted to those regions of the coral which are interspersed with polyps; allogenic fusion is observed between branches, with a high density of polyps and the “foot”-region, which is characterized by a low polyp density.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304421
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  • 5
    Electronic Resource
    Electronic Resource
    Histochemical localization of high-sulfur keratins with silver nitrate (1983)
    Springer
    Colloid & polymer science 261 (1983), S. 365-369 
    Details
    ISSN: 1435-1536
    Keywords: wool ; electron-microscopy ; silver staining ; atomic absorption spectrophotometry ; silver content
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The treatment of merino wool with ammoniacal silver nitrate results in a selective staining of high-sulfur proteins. The method has been applied to unmodified and reduced fibres. The electron microscopical studies are supplemented by a quantitative analysis by means of atomic absorption spectrophotometry. At the saturation point no difference in the silver uptake of reduced and unreduced fibres can be established. However, the samples show considerable differences regarding the kinetics of the reaction. The photometric analysis yields a silver uptake of 3 mol Ag/mol cysteine and 6 mol Ag/mol cystine. The silver deposition depends upon the formation of silver mercaptide and silver complexes of unknown structure. In comparison with cysteine the mercaptide formation from cystine occurs very slowly, because the disulfide bond first has to be cleaved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01413944
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  • 6
    Electronic Resource
    Electronic Resource
    In memoriam Henry John Woods (1984)
    Springer
    Colloid & polymer science 262 (1984), S. 839-840 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01452212
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  • 7
    Electronic Resource
    Electronic Resource
    Cell-cell recognition system in gorgonians: description of the basic mechanism (1983)
    Springer
    Marine biology 76 (1983), S. 1-6 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The dissociation of the gorgonian Eunicella cavolinii (Koch) into single cells was successfully accomplished. These cells readily formed aggregates of a size of 2 100 μm during incubation in roller tubes; no aggregate formation was observed in non-rotating Petri dishes. The formation of aggregates was not influenced by Ca++, urea or trypsin; it was also independent of temperature (4° to 30°C) and pH (5.5–9.0). The intercellular material of the gorgonian contains a galactose-specific lectin, as determined by double diffusion experiments and haemagglutination inhibition experiments using a series of galactoglycoconjugates. This lectin converted the aggregation-susceptible cells to aggregation-deficient cells. These findings are summarized in a novel model, in which it is assumed that the lectin masks the function of the cell surface-associated aggregation molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393049
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  • 8
    Electronic Resource
    Electronic Resource
    Herstellung von Argininpeptiden mitN 7,N 8-(1,2-Dihydroxycyclohex-1,2-ylen)-Schutz (1982)
    Springer
    Monatshefte für Chemie 113 (1982), S. 457-473 
    Details
    ISSN: 1434-4475
    Keywords: Activation, lactam-formation, side-reactions ; N7,N8-(1,2-Dihydroxycyclohex-1,2-ylen)-arginine-derivatives and -peptides ; Semisynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A method for the synthesis of arginine peptides is described, in which the side chain guanidine function is blocked through reaction with 1,2-cyclohexanedione in borate buffers. Coupling to the carboxyl group of arginine was achieved by active ester, by dicyclohexylcarbodiimide/1-hydroxybenzotriazole1, and by the mixed anhydride methods2. Neither lactam formation nor acylation of the vicinal hydroxyls of the N7, N8-(1,2-dihydroxycyclohex-1,2-ylene) guanidino group was observed. Removal of the protecting group is strongly influenced by steric factors. Some side reactions observed during modification of peptides and protein fragments with 1,2-cyclohexanedione are also described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799922
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  • 9
    Electronic Resource
    Electronic Resource
    On the further development of the resonating group approach (1982)
    Springer
    Czechoslovak journal of physics 32 (1982), S. 288-290 
    Details
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Calculations in the framework of the refined resonating group method (RRGM) have been particularly successful in describing light nuclear systems with mass numbers 3 ≦ A ≦ 12 in the low-energy domain. Further developments of this approach to extend the realm of applicability beyond its present limits are introduced. We merge SU3-cluster model and RRGM techniques for the investigation of higher mass numbers (A ≦ 28), incorporate one-body operators for the description of, e.g., photo-induced processes, and add polynomials in the intercluster functions to allow the description of medium-energy processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01602070
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  • 10
    Electronic Resource
    Electronic Resource
    Toxic effects in fish and the mutagenic capacity of water from the Sava River in Yugoslavia (1981)
    Springer
    Bulletin of environmental contamination and toxicology 26 (1981), S. 179-187 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622073
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