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  • Cambridge University Press  (6)
  • American Association for the Advancement of Science (AAAS)  (4)
  • American Meteorological Society
  • Amsterdam : Elsevier
  • 1980-1984  (10)
Collection
Keywords
Publisher
Years
Year
  • 1
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    Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-21
    Description: Rat embryo fibroblasts transformed by Abelson murine leukemia virus (MuLV) produce and release a transforming growth factor (TGF). Production of this factor is correlated with a tyrosine-specific protein kinase that is functionally active and is associated with the major Abelson MuLV gene product, P120. Transformation-defective mutants of Abelson MuLV do not transform cells, do not have their virus coded transforming gene product phosphorylated in tyrosine, and do not induce TGF production. Abelson MuLV-induced TGF morphologically transforms cells in culture, competes with 125I-labeled epidermal growth factor (EGF) for binding to cell receptors, and induces phosphorylation of tyrosine acceptor sites in the 160,000-dalton EGF membrane receptor. After purification to homogeneity, Abelson virus-induced TGF migrates as a single polypeptide with an apparent size of 7400 daltons as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Twardzik, D R -- Todaro, G J -- Marquardt, H -- Reynolds, F H Jr -- Stephenson, J R -- New York, N.Y. -- Science. 1982 May 21;216(4548):894-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6177040" target="_blank"〉PubMed〈/a〉
    Keywords: Abelson murine leukemia virus ; Animals ; *Cell Transformation, Neoplastic ; *Cell Transformation, Viral ; Molecular Weight ; Peptides/*metabolism ; Phosphotyrosine ; Rats ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; Transforming Growth Factors ; Tyrosine/analogs & derivatives/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Isolation of human oncogene sequences (v-fes homolog) from a cosmid library (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-04
    Description: To define the human homolog (or homologs) of transforming sequences (v-fes gene) common to Gardner (GA) and Snyder Theilen (ST) isolates of feline sarcoma virus (FeSV), a representative library of human lung carcinoma DNA in a cosmid vector system was constructed. Three cosmid clones were isolated containing GA/ST FeSV v-fes homologous cellular sequences, within 32- to 42-kilobase cellular inserts representing 56 kilobases of contiguous human cellular DNA. Sequences both homologous to, and colinear with, GA or ST FeSV v-fes are distributed discontinuously over a region of up to 9.5 kilobases and contain a minimum of three regions of nonhomology representing probable introns. A thymidine kinase selection system was used to show that, upon transfection to RAT-2 cells, the human c-fes sequence lacked detectable transforming activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Groffen, J -- Heisterkamp, N -- Grosveld, F -- Van de Ven, W -- Stephenson, J R -- N0I-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 4;216(4550):1136-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281890" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteriophage lambda/genetics ; *Cell Transformation, Viral ; Cloning, Molecular/methods ; DNA Restriction Enzymes ; DNA, Recombinant ; Escherichia coli/genetics ; *Genes, Viral ; Humans ; Retroviridae/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Sex preselection in mammals? Separation of sperm bearing Y and "O" chromosomes in the vole Microtus oregoni (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: The two sex determining sperm populations of the vole Microtus oregoni were separated according to DNA content by use of flow sorting instrumentation. Although the sperm were not viable, they should be useful for addressing the question of haploid expression of genes linked to sex chromosomes and for efficiently searching for biochemical markers that differentiate the two populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pinkel, D -- Gledhill, B L -- Lake, S -- Stephenson, D -- Van Dilla, M A -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):904-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arvicolinae/genetics ; DNA/analysis ; Flow Cytometry/methods ; Fluorescent Dyes ; Male ; Sex Chromosomes/ultrastructure ; *Sex Determination Analysis ; Spermatozoa/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Role of the conserved AAUAAA sequence: four AAUAAA point mutants prevent messenger RNA 3' end formation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickens, M -- Stephenson, P -- R-R01-GM31892-02/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1045-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6208611" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Female ; Genes, Viral ; *Mutation ; Nucleic Acid Hybridization ; Oocytes/metabolism ; Poly A/genetics ; RNA/genetics ; RNA, Messenger/*genetics ; Simian virus 40/*genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    British polar exploration 10 years before and after World War II: a Comparison (1981)
    Cambridge University Press
    Details
    Publication Date: 1981-01-01
    Description: In the Foreword to the first issue of Polar Record the editor wrote: ‘In the first place an attempt will be made merely to record the chief polar events of the preceding six months; but it is hoped that the scope of the journal will gradually be extended. The main body of The Polar Record, therefore, is a resume of polar news extracted from the best available sources’. This was a formidable task even in 1931, and a cursory glance at the latest volume indicates the tremendous growth and advances that have taken place since then. It is an impressive record and to mark the journal's 50th anniversary I shall use this information to make a general comparison of British polar activities, and the driving force behind them, in the pre- and post-war periods.
    Print ISSN: 0032-2474
    Electronic ISSN: 1475-3057
    Topics: Ethnic Sciences , Geography
    Published by Cambridge University Press
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  • 6
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    Radioisotope Detection with the Argonne FN Tandem Accelerator (1980)
    Cambridge University Press
    Details
    Publication Date: 1980-01-01
    Description: A standard heavy ion nuclear structure facility has been used to detect several long-lived radioisotopes by counting the accelerated ions. The problem of eliminating strong isobaric background beams has been solved by combining the energy loss dispersion through a uniform Al foil stack with the high momentum resolution of an Enge split-pole magnetic spectrograph. Radioisotope concentrations in the following ranges have been measured: 14C/12C = 10–12 to 10–13, 26Al/27Al = 10–10 to 10–12, 32Si/Si = 10–8 to 10–14, 36Cl/Cl = 10–8 to 10–11.
    Print ISSN: 0033-8222
    Electronic ISSN: 1945-5755
    Topics: Archaeology , Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Published by Cambridge University Press
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  • 7
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    Dynamic behaviour of rutford ice stream (1982)
    Cambridge University Press
    Details
    Publication Date: 1982-01-01
    Description: The grounding-line region of Rutford Ice Stream was surveyed from the ground during 1978–79 and 1979–80, and from the air in 1980–81. Maps of surface elevation and ice thickness of an area of 1 000 km2allow the grounding line to be delineated and show that the ice stream consists of several distinct fingers of thick ice trending parallel to the flow. In one area, the floating ice is more than 2 000 m thick. Hydrostatic tiltmeters were used to pinpoint the grounding line. Repeated survey of a network of stakes gave velocity and strain-rates for both longitudinal and transverse profiles. Radio echo-fading pattern studies showed the ice to be completely sliding near the grounding line. Modelling of the ice stream, using steady-state theory, shows that the bottom melting rate is around 1.8 m a−1. The small surface and bottom gradients imply that the position of the grounding line may be sensitive to small changes in ice thickness.
    Print ISSN: 0260-3055
    Electronic ISSN: 1727-5644
    Topics: Geography , Geosciences
    Published by Cambridge University Press on behalf of International Glaciological Society.
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  • 8
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    Dynamic behaviour of rutford ice stream (1982)
    Cambridge University Press
    Details
    Publication Date: 1982-01-01
    Description: The grounding-line region of Rutford Ice Stream was surveyed from the ground during 1978–79 and 1979–80, and from the air in 1980–81. Maps of surface elevation and ice thickness of an area of 1 000 km2 allow the grounding line to be delineated and show that the ice stream consists of several distinct fingers of thick ice trending parallel to the flow. In one area, the floating ice is more than 2 000 m thick. Hydrostatic tiltmeters were used to pinpoint the grounding line. Repeated survey of a network of stakes gave velocity and strain-rates for both longitudinal and transverse profiles. Radio echo-fading pattern studies showed the ice to be completely sliding near the grounding line. Modelling of the ice stream, using steady-state theory, shows that the bottom melting rate is around 1.8 m a−1. The small surface and bottom gradients imply that the position of the grounding line may be sensitive to small changes in ice thickness.
    Print ISSN: 0260-3055
    Electronic ISSN: 1727-5644
    Topics: Geography , Geosciences
    Published by Cambridge University Press on behalf of International Glaciological Society.
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  • 9
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    Glacier Flexure and the Position of Grounding Lines: Measurements By Tiltmeter on Rutford Ice Stream, Antarctica (1984)
    Cambridge University Press
    Details
    Publication Date: 1984-01-01
    Description: Two methods were used to locate the grounding line on the Rutford Ice Stream. The first method determined where the glacier was floating in hydrostatic equilibrium, while the second method measured the flexing close to the grounding line due to ocean tides. The ratio of surface elevation to ice thickness of the glacier goes through the hydrostatic equilibrium value 1 to 2 km downstream of where tidal flexing was recorded. This behaviour can be explained if the upward pressure of the sea at the base of the ice is augmented by a vertical shear-stress gradient within the glacier to overcome its weight. Simple el as tie-beam theory matches the flexure profile data if a modified elastic modulus and effective thickness are used. Tiltmeters can he used to monitor the position of the grounding line if the geometry of the flexing region can be defined.
    Print ISSN: 0260-3055
    Electronic ISSN: 1727-5644
    Topics: Geography , Geosciences
    Published by Cambridge University Press on behalf of International Glaciological Society.
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  • 10
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    Glacier Flexure and the Position of Grounding Lines: Measurements By Tiltmeter on Rutford Ice Stream, Antarctica (1984)
    Cambridge University Press
    Details
    Publication Date: 1984-01-01
    Description: Two methods were used to locate the grounding line on the Rutford Ice Stream. The first method determined where the glacier was floating in hydrostatic equilibrium, while the second method measured the flexing close to the grounding line due to ocean tides. The ratio of surface elevation to ice thickness of the glacier goes through the hydrostatic equilibrium value 1 to 2 km downstream of where tidal flexing was recorded. This behaviour can be explained if the upward pressure of the sea at the base of the ice is augmented by a vertical shear-stress gradient within the glacier to overcome its weight. Simple el as tie-beam theory matches the flexure profile data if a modified elastic modulus and effective thickness are used. Tiltmeters can he used to monitor the position of the grounding line if the geometry of the flexing region can be defined.
    Print ISSN: 0260-3055
    Electronic ISSN: 1727-5644
    Topics: Geography , Geosciences
    Published by Cambridge University Press on behalf of International Glaciological Society.
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