Publication Date:
1982-08-20
Description:
Action potentials were silenced in one eye of neonatal kittens by repeated intraocular injections of tetrodotoxin for 5 to 8 weeks. After tetrodotoxin blockade was allowed to wear off, receptive field properties of individual relay cells in the lateral geniculate nucleus were examined. The many ON-OFF and binocular fields found in the layers that receive input from the treated eye suggest that these cells had extremely abnormal retino-geniculate synaptic connections. These effects were different in kind from those seen after deprivation rearing that does not silence action potentials. Lack of action potential activity was concluded to lead to abnormal development in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Archer, S M -- Dubin, M W -- Stark, L A -- 7F32 EY 05442/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):743-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100921" target="_blank"〉PubMed〈/a〉
Keywords:
*Action Potentials
;
Animals
;
Animals, Newborn
;
Cats/*growth & development
;
Evoked Potentials, Visual
;
Facial Nerve/*growth & development
;
Geniculate Ganglion/*growth & development
;
Optic Nerve/growth & development
;
Retina/*growth & development
;
Sensory Deprivation
;
Synapses/physiology
;
Tetrodotoxin/pharmacology
;
Visual Pathways/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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