ISSN:
1432-0827
Keywords:
Isoproterenol
;
Dopamine
;
Propranolol
;
PTH
;
Calcitonin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Summary Available evidencein vitro andin vivo suggests that pharmacologic doses of isoproterenol stimulate the secretion of parathyroid hormone (PTH) and calcitonin (CT) and propranolol inhibits secretion. However, the findings in man are either quite modest or inconsistent. In view of this controversy, we examined the effects of isoproterenol, 0.15 µg intradermally (i.d.), dopamine, 5 µg/kg body weight over 60 min intravenously (i.v.), and propranolol, 1 mg over 5 min followed by 60 µg per min for 2 i.v. in normal human subjects. It was found that these agents did not alter serum calcium, serum immunoreactive PTH, or plasma immunoreactive CT. The findings do not support a physiologic role for biogenic amines in the control and regulation of PTH or CT secretion in normal man.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02405003
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