Publication Date:
1981-04-24
Description:
Purified DNA of Epstein-Barr virus (EBV) is regularly infectious by means of the "calcium" method of transfection. Cultured human placental cells exposed to EBV DNA of two transforming strains, FF41 and B95, produce virus that is capable of converting normal B lymphocytes into established cell lines. After treatment with EBV (FF41) DNA and EBV (HR-1) DNA the placental cells display antigens associated with the productive viral cycle. The placental cells have not developed foci or other signs of morphologic transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, G -- Grogan, E -- Heston, L -- Robinson, J -- Smith, D -- AI 14741/AI/NIAID NIH HHS/ -- CA 12055/CA/NCI NIH HHS/ -- CA 16038/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):452-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259735" target="_blank"〉PubMed〈/a〉
Keywords:
Antigens, Viral/analysis
;
B-Lymphocytes/immunology/microbiology
;
Capsid/immunology
;
*Cell Transformation, Viral
;
DNA, Viral/*genetics
;
Herpesvirus 4, Human/*genetics/immunology
;
Humans
;
Placenta/*microbiology
;
*Transfection
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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