Publication Date:
1982-01-22
Description:
7-Hydroxymethyl-12-methylbenz[alpha]anthracene (7-HMBA), a carcinogenic major metabolite of 7,12-dimethylbenz[alpha]anthracene (DMBA) in liver, was transformed by liver cytosolic sulfotransferase to reactive 7-HMBA sulfate, which is mutagenic toward Salmonella typhimurium strain TA98. The mutagenicity of 7-HMBA in the presence of hepatic sulfotransferase was much higher than that of DMBA or 7-HMBA in the presence of hepatic monooxygenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watabe, T -- Ishizuka, T -- Isobe, M -- Ozawa, N -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):403-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6800033" target="_blank"〉PubMed〈/a〉
Keywords:
9,10-Dimethyl-1,2-benzanthracene/analogs & derivatives/*metabolism/pharmacology
;
Benz(a)Anthracenes/*metabolism
;
Biotransformation
;
Mutagenicity Tests
;
*Mutagens
;
Salmonella typhimurium/drug effects
;
Structure-Activity Relationship
;
Sulfuric Acids
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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