Publication Date:
1980-04-25
Description:
Hydralazine, the prototypic drug that induces systemic lupus erythematosus, reacts with thymidine and deoxycytidine. Analysis of a reaction mixture of therapeutic concentrations of hydralazine with labeled thymidine reveals at least four labeled products. At higher concentrations, hydralazine reacts with labeled deoxycytidine to form at least three labeled products. Formation of these products is markedly enhanced by exposure to ultraviolet light. The reaction of hydralazine with thymidine and deoxycytidine may be in part responsible for initiating drug-induced systemic lupus erythematosus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dubroff, L M -- Reid, R J Jr -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):404-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367866" target="_blank"〉PubMed〈/a〉
Keywords:
DNA/immunology
;
*Hydralazine
;
Lupus Erythematosus, Systemic/*chemically induced/immunology
;
Photochemistry
;
*Pyrimidines/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink