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  • 1
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    Opiate analgesia: evidence for mediation by a subpopulation of opiate receptors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: Naloxazone, a hydrazone derivative of the opiate antagonist naloxone, has a high affinity for opiate receptor binding sites. Naloxazone injections reduce opiate receptor binding to extensively washed mouse brain membranes for more than 24 hours, suggesting that the effect is irreversible. High-affinity binding sites are abolished by this treatment, whereas low-affinity sites are unaffected. Naloxazone treatment blocks the analgesic effects of morphine for at least 24 hours but does not prevent death from high doses of morphine. Thus analgesic but nonlethal opiate effects may be mediated by the high-affinity subpopulation of opiate receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pasternak, G W -- Childers, S R -- Snyder, S H -- New York, N.Y. -- Science. 1980 May 2;208(4443):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites/drug effects ; Brain/metabolism ; Mice ; Morphine/pharmacology/toxicity ; Naloxone/adverse effects/*analogs & derivatives/pharmacology ; Receptors, Opioid/classification/*drug effects/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peroutka, S J -- Snyder, S H -- 5T32GM0309/GM/NIGMS NIH HHS/ -- DA00266/DA/NIDA NIH HHS/ -- MH18501/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):88-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents/administration & dosage/metabolism/*pharmacology ; Frontal Lobe/drug effects ; Male ; Rats ; Receptors, Adrenergic, alpha/metabolism ; Receptors, Adrenergic, beta/drug effects/metabolism ; Receptors, Dopamine/metabolism ; Receptors, Histamine H1/metabolism ; Receptors, Muscarinic/metabolism ; Receptors, Serotonin/*drug effects/metabolism ; Spiperone/metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Neurotransmitter receptor binding in bovine cerebral microvessels (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-09
    Description: Purified preparations of microvessels from bovine cerebral cortex contain substantial levels of alpha-adrenergic, beta-adrenergic, and histamine 1 receptor binding sites but only negligible serotonin, muscarinic cholinergic, opiate, and benzodiazepine receptor binding. Norepinephrine and histamine may be endogenous regulators of the cerebral microcirculation at the observed receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peroutka, S J -- Moskowitz, M A -- Reinhard, J F Jr -- Snyder, S H -- New York, N.Y. -- Science. 1980 May 9;208(4444):610-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6102801" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Cattle ; Ligands ; Microcirculation ; Neurotransmitter Agents/*metabolism ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, alpha/metabolism ; Receptors, Adrenergic, beta/metabolism ; Receptors, Cholinergic/metabolism ; Receptors, Histamine/*metabolism ; Receptors, Histamine H1/*metabolism ; Receptors, Serotonin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R R -- Kuhar, M J -- Hester, L -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 27;220(4600):967-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302841" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*physiology ; Animals ; Autoradiography ; Axons/*physiology ; Cerebellum/physiology ; Corpus Striatum/physiology ; Hippocampus/physiology ; Mice ; Mice, Neurologic Mutants ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*physiology ; Receptors, Purinergic ; Retinal Ganglion Cells/physiology ; Synaptic Membranes/physiology ; Thalamus/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Solubilized adenosine receptors in the brain: regulation of guanine nucleotides (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-26
    Description: Adenosine receptors associated with a reduction of adenylate cyclase and labeled by tritium-labeled cyclohexyladenosine can be solubilized from brain membranes with sodium cholate. Regulation of receptor binding by guanine nucleotides is retained in the soluble state. Influences of cations observed in membrane preparations of adenosine receptors are no longer detected with the solubilized receptors. The apparent retention of a complex of receptors and guanosine triphosphate binding but not cation binding protein in the soluble state may permit a molecular analysis of receptor regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gavish, M -- Goodman, R R -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1633-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280275" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*physiology ; Animals ; Brain/*physiology ; Cations, Divalent/pharmacology ; Cattle ; Cell Membrane/metabolism ; Guanine Nucleotides/*pharmacology ; Receptors, Cell Surface/*drug effects ; Receptors, Purinergic ; Solubility
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Phorbol ester receptors: autoradiographic identification in the developing rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-02
    Description: Autoradiography with 3H-labeled phorbol dibutyrate was used for the light microscopic detection of phorbol ester receptors in rat fetuses. In 15- and 18-day fetuses, as well as in adult rats, receptors were found to be concentrated in the central nervous system. The localization of receptors in the ventral marginal zone of the fetal neural tube, the lens of the eye, and other sites suggests a role for phorbol ester receptors in cellular process extension and cell-cell interaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, K M -- Gould, R J -- Oster-Granite, M L -- Gearhart, J D -- Snyder, S H -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):1036-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316499" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Brain/embryology ; Brain Chemistry ; *Caenorhabditis elegans Proteins ; Carrier Proteins ; Cell Communication ; Cell Division ; Central Nervous System/analysis/*embryology ; Eye/embryology ; Fetus/*analysis ; Intestines/embryology ; Lens, Crystalline/embryology ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/*metabolism ; Phorbols/*metabolism ; *Protein Kinase C ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*analysis ; *Receptors, Drug
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Two distinct central serotonin receptors with different physiological functions (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peroutka, S J -- Lebovitz, R M -- Snyder, S H -- DA-00074/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 May 15;212(4496):827-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221567" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Behavior, Animal/*physiology ; Brain/*physiology ; Guanine Nucleotides/physiology ; Kinetics ; Male ; Rats ; Receptors, Serotonin/*physiology ; Serotonin/metabolism ; Spiperone/metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Recognition sites for norepinephrine uptake: regulation by neurotransmitter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Recognition sites for the uptake of norepinephrine on adrenergic neurons in the brain and periphery were labeled with [3H]desipramine. The number of these uptake sites varied with the concentration of transmitter; depletion of norepinephrine with reserpine reduced the number of uptake sites, whereas increasing the concentration of norepinephrine induced by treatment with monoamine oxidase inhibitors raised the number of binding sites. These dynamic alterations in norepinephrine uptake recognition sites may regulate synaptic function homeostatically, providing less inactivation of reuptake when the synaptic concentration of the transmitter is low and increased inactivation when it is high.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, C M -- Javitch, J A -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 6;220(4597):626-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301013" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Chemistry/drug effects ; Cerebral Cortex/analysis ; Desipramine/metabolism ; Dihydroalprenolol/metabolism ; Iproniazid/pharmacology ; Norepinephrine/analysis/*metabolism/physiology ; Rats ; Receptors, Adrenergic/drug effects/*physiology ; Reserpine/pharmacology ; Salivary Glands/analysis ; Synapses/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Brain peptides as neurotransmitters (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-29
    Description: Numerous peptides appear to be neurotransmitter candidates in the brain. Some, such as the opioid peptide enkephalins, neurotensin, and substance P, were first isolaterd from the brain. Peptides, such as cholecystokinin and vasoactive intestinal polypeptide, were known as intestinal hormones and later recognized as brain constituents. Certain hypothalamic-releasing hormones, pituitary peptides, and blood-derived peptides like angiotensin II and bradykinin, may also be central neurotransmitters. The diversity of localization of these peptides throughout the brain implies a multiplicity of potential roles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyder, S H -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):976-83.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157191" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensins/physiology ; Animals ; Bradykinin/physiology ; Brain/*physiology ; Carnosine/physiology ; Cholecystokinin/physiology ; Endorphins/physiology ; Gastrins/physiology ; Glucagon/physiology ; Humans ; Insulin/physiology ; Nerve Tissue Proteins/physiology ; Neurotensin/physiology ; Peptides/*physiology ; Pituitary Hormone-Releasing Hormones/physiology ; Receptors, Opioid/physiology ; Substance P/physiology ; Vasoactive Intestinal Peptide/physiology ; Vasopressins/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Drug and neurotransmitter receptors in the brain (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-06
    Description: Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade. This work has permitted fundamental insights into how binding of neurotransmitters to their receptors excites or inhibits neuronal firing or changes cellular metabolism. The recognition of receptor subtypes has suggested subtle ways for neurotransmitters to modulate neuronal functioning. Finally, the ability to measure receptor sites in simple test tube systems and to distinguish readily between agonists and antagonists has provided useful probes for drug discovery programs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):22-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322304" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism/physiology ; Brain Chemistry ; Calcium Channel Blockers/metabolism ; Cerebellum/metabolism ; Humans ; Rabbits ; Rats ; Receptors, Adrenergic/metabolism ; Receptors, Catecholamine ; Receptors, Cell Surface/metabolism ; Receptors, Dopamine/metabolism ; Receptors, Drug/analysis/*metabolism/physiology ; Receptors, GABA-A ; Receptors, Neurotransmitter/analysis/*metabolism/physiology ; Receptors, Opioid/metabolism ; Receptors, Purinergic ; Receptors, Serotonin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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