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  • Bone resorption  (2)
  • Springer  (2)
  • 1980-1984  (2)
  • 1965-1969
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  • Springer  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Failure of cells of the mononuclear phagocyte series to resorb bone (1984)
    Springer
    Calcified tissue international 36 (1984), S. 556-558 
    Details
    ISSN: 1432-0827
    Keywords: Osteoclast ; Bone resorption ; Mononuclear phagocytes ; Monocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Monocytes, peritoneal macrophages, inflammatory polykaryons, and myeloid cell lines were incubated on slices of human cortical bone and assessed for their capacity to resorb bone by scanning electron microscopy. None of these cell types, mononuclear or multinucleate, induced any detectable change in the bone surface, even after prolonged incubation, and even in the presence of macrophage activators. These findings emphasise the inadequacies of mononuclear phagocytes as surrogate osteoclasts, and expose a discrepancy between45Ca release and bone resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405365
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  • 2
    Electronic Resource
    Electronic Resource
    Cyclo-oxygenase products of arachidonic acid metabolism in rat osteoblasts in culture (1983)
    Springer
    Calcified tissue international 35 (1983), S. 294-297 
    Details
    ISSN: 1432-0827
    Keywords: Prostaglandins ; Osteoblasts ; Bone resorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The metabolism of arachidonic acid to its cyclo-oxygenase products was studied in monolayer cultures of osteoblast-rich rat calvarial cells and of clonal cell lines from a rat osteogenic sarcoma, enriched in the osteoblast phenotype. Prostanoids were measured by radioimmunoassay after extraction of media and fractionation by high pressure liquid chromatography. In both normal and malignant osteoblasts the major cyclo-oxygenase product was 6-oxo-prostaglandin F1α, the hydration product of prostacyclin, with lesser amounts of prostaglandin E2 and prostaglandin F2α. No significant thromboxane B2 was detected. Prostaglandins are thought to have a local role in the regulation of bone resorption. These results point to the possible importance of prostacyclin either in bone resorption or in some other local function, e.g., regulation of bone blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405049
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    Paper (German National Licenses)
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