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  • 1
    Electronic Resource
    Electronic Resource
    Steady-state and transient studies of carbon monoxide oxidation on alumina-supported rhodium via transmission infrared spectroscopy (1988)
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 27 (1988), S. 1396-1407 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie00080a012
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  • 2
    Electronic Resource
    Electronic Resource
    Redirection of Cellular Metabolism (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 506 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb23807.x
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  • 3
    Electronic Resource
    Electronic Resource
    Fermentation Patterns and Macromolecular Composition of Immobilized and Suspended Yeast during Biotin Starvation (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 501 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb45730.x
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of plasmid presence on growth and enzyme activity of Escherichia coli DH5α (1989)
    Springer
    Applied microbiology and biotechnology 32 (1989), S. 54-60 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The effects of recombinant DNA propagation and gene expression on the physiology of the host cell was investigated using a series of copy number mutant plasmids. The plasmids at copy numbers of 30, 57, 115 and 501 per chromosome equivalent encoded constitutive production of the enzyme β-lactamase. Ribose phosphate isomerase activity was relatively unaffected by plasmid presence, and glucose-6-phosphate dehydrogenase, fructose 1,6-diphosphate aldolase and fructose 1,6-diphosphatase activities were lower in plasmid-containing cells than in the plasmid-free host strain. Increasing copy number resulted in increased depression of enzyme activity levels. The results indicate that plasmid presence mediates subtle changes in the net expression of host enzymes involved in carbon metabolism. Responses of Escherichia coli DH5α in Evans medium to these plasmids differed substantially from responses of E. coli HB101 in rich medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164823
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  • 5
    Electronic Resource
    Electronic Resource
    Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli (1988)
    [s.l.] : Nature Publishing Group
    Nature 331 (1988), S. 633-635 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recently, Wakabayashi et a/.11 reported the primary amino-acid sequence of a soluble dimeric haemoglobin found in the obligately aerobic bacterium, Vitreoscilla, and demonstrated significant similarity of this protein with known globin sequen-ces.The synthesis of this protein increases severalfold ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/331633a0
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  • 6
    Electronic Resource
    Electronic Resource
    The Vitreoscilla hemoglobin gene: Molecular cloning, nucleotide sequence and genetic expression in Escherichia coli (1988)
    Springer
    Molecular genetics and genomics 214 (1988), S. 158-161 
    Details
    ISSN: 1617-4623
    Keywords: Vitreoscilla ; Hemoglobin ; Cloning ; Nucleotide sequence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Vitreoscilla hemoglobin is involved in oxygen metabolism of this bacterium, possibly in an unusual role for a microbe. We have isolated the Vitreoscilla hemoglobin structural gene from a pUC19 genomic library using mixed oligodeoxy-nucleotide probes based on the reported amino acid sequence of the protein. The gene is expressed in Escherichia coli from its natural promoter as a major cellular protein. The nucleotide sequence, which is in complete agrecment with the known amino acid sequence of the protein, suggests the existence of promoter and ribosome binding sites with a high degree of homology to consensus E. coli upstream sequences. In the case of at least some amino acids, a codon usage bias can be detected which is different from the biased codon usage pattern in E. coli. The down-stream sequence exhibits homology with the 3′ end sequences of several plant leghemoglobin genes. E. coli cells expressing the gene contain greater than fivefold more heme than controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340195
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  • 7
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of volatile anesthetic agent elimination: A theoretical study (1989)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 17 (1989), S. 109-123 
    Details
    ISSN: 1573-8744
    Keywords: anesthetics, gases ; pharmacokinetics ; volatile anesthetics ; inhalation agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The theoretical groundwork for a rate constant formulation of inhaled anesthetic elimination kinetics is discussed. In an effort to simulate recent experimental results a linear flow-limited five-compartment model was used comprising lung, vessel-rich tissue, muscle, nonvisceral fat, and an additional compartment, marrow-visceral fat whose functional existence recently has been experimentally demonstrated. Hypothetical but plausible parameters for the marrow-visceral fat compartment were used. The theoretically predicted values were in good agreement with experimental results suggesting that this model is appropriate for the elimination kinetics of agents that are not metabolized to any significant degree. Simple approximate expressions for the rate constants were also derived and were in reasonable agreement with experimental results. The model was also employed to clarify the effect of anesthetic duration on subsequent elimination kinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059090
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  • 8
    Electronic Resource
    Electronic Resource
    Aggregation kinetics in salt-induced protein precipitation (1989)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 35 (1989), S. 1779-1790 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The kinetics of protein aggregation in salt-induced precipitation processes were studied as a function of salt type, salt concentration, temperature and protein concentration. α-chymotrypsin (αCT) was used as a model protein. Stopped-flow turbidimetry was used to monitor the progress of precipitations. Analysis of the linear portions of the turbidity trajectories indicates that temperature and salt concentration effects are related to protein solubility; the protein concentration dependence is well described by the Smoluchowski collision equation. The aggregation kinetics of partially-inhibited αCT exhibit poisoning behavior, underscoring the importance of dimerization and monomer addition in the precipitation of αCT. Solute particle radius distributions determined via dynamic laser light scattering for low salt and supernatant αCT solutions indicated that significant aggregation does not occur in the absence of supersaturation. A detailed population balance model was proposed that accounted for specific and nonspecific interactions and monomer addition. The model is expected to find general application to protein aggregation phenomena, in particular for proteins that have specific quaternary interactions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690351104
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of recombinant plasmid content on growth properties and cloned gene product formation in Escherichia coli (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 1668-1674 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Plasmid-host cell interactions have been investigated experimentally using Escherichia coli HB101, plasmid RSF1050 which contains the origin of replication of pMB1, and four other closely related copy number mutant plasmids. Growth characteristics of these recombinant strains and β-lactamase activity expressed from a plasmid gene were investigated in Luria broth (LB) and in minimal medium (M9) containing in some cases casamino acids or different concentrations of α-methylglucoside, a competitive inhibitor of glucose transport. Maximum specific growth rates in LB and minimal media were reduced for increasing plasmid content per cell. Plasmid copy number increased when specific growth rate was reduced by changing medium composition. Growth rates of high copy number strains were less sensitive to α-methylglucoside than lower copy number strains and the plasmidfree host. The overall efficiency of plasmid gene expression, measured as the ratio of β-lactamase specific activity to plasmid content, decreased significantly with increasing plasmid content in LB medium.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260271207
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  • 10
    Electronic Resource
    Electronic Resource
    A kinetic model for product formation in unstable recombinant populations (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 1699-1709 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model has been formulated for product formation by unstable recombinant organisms in batch and in continuous flow reactors. The cell population is characterized by three different genotypes according to the absence or presence of plasmids (segregational instability) and of active cloned gene (structural instability). Empirical growth inhibition factors due to plasmids and to product protein are assigned to the corresponding strains. Product formation kinetics are based upon a quasi-steady-state transcription-translation expression model. An approximate form of these mechanism-based product formation kinetics is identical to the traditional, empirically based Leudeking-Piret formula. Alternative models which consider inhibition based on overall product concentration and based on intracellular product concentration are posed, and their implications are compared. Simulation results based on these models indicate (1) overall plasmid stability depends on product expression and reactor operating conditions as well as on intrinsic segregation and mutation rate parameters; (2) there exists an optimum combination of plasmid copy number and cloned-gene transcription and translation efficiencies to maximize reactor productivity; and (3) continuous reactor dilution rate influences the fraction of productive cells. General trends and substrate, product, and cell concentration time trajectories obtained from model simulation agree well qualitatively with currently available experimental information.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260271211
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