Publication Date:
1985-01-04
Description:
The T antigen proteins encoded by DNA tumor virus early genes are involved in the transformation of normal cells to immortalized neoplastic cells that may or may not be tumorigenic in immunocompetent animals. Studies have been made of the tumorigenicity of DNA virus-transformed cells and the interactions of these cells in vivo and in vitro with immunologically nonspecific host effector cells such as natural killer cells and macrophages. The results imply that the T proteins determine the capacity of transformed cells to induce tumors by governing the level of susceptibility that transformed cells express to destruction by such host cellular defenses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewis, A M Jr -- Cook, J L -- CA 31732/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):15-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3843807" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Polyomavirus Transforming
;
Antigens, Viral, Tumor/*metabolism
;
Cell Line
;
Cell Transformation, Neoplastic/immunology/*metabolism
;
*Cell Transformation, Viral
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Cricetinae
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Cytotoxicity, Immunologic
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DNA Viruses/*metabolism
;
Humans
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Immunity, Cellular
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Killer Cells, Natural/immunology
;
Major Histocompatibility Complex
;
Mesocricetus
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Neoplasms, Experimental/immunology
;
Rats
;
Viral Proteins/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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