ISSN:
0268-2605
Keywords:
Organotin
;
toxicity
;
total surface area
;
quantitative structure-activity relationships
;
molecular topology
;
N2a neuroblastoma cells
;
3T3 fibroblasts
;
Daphnia magna
;
Rhithropanopeus harrisii
;
Ankistrodesmus falcatus
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
There exists a high correlation between molecular total surface area (TSA) values and diorganotin toxicity towards several distinct types of organisms. This correlation was found for N2a neuroblastoma cells, 3T3 fibroblasts, Daphnia magna Rhithropanopeus harrisii and Ankistrodesmus falcatus. In the case of Rhithropanopeus harrisii, a high correlation was also found between TSA and toxicity for triorganotins as well. This study suggests that the relationship between TSA and toxicity is a function of the hydrophobicity of the organotin compounds rather than electronic or steric effects.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590020211
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