ISSN:
1573-4986
Keywords:
9-amino-NeuAc
;
sialidase resistance
;
sialidases
;
sialic acid analogue
;
resialylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract We demonstrate that 9-amino-NeuAc transferred to asialo-α1-acid glycoprotein resists cleavage by bacterial, viral and mammalian sialidases. This is the first synthetic sialic acid analogue, which can be activated and transferred to glycoprotein, but is not a sialidase (EC 3.2.1.18) substrate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01049916
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