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Characterization of hydrates of norfloxacin (1986)

Katdare, A. V. ; Ryan, J. A. ; Bavitz, J. F. ; [et al.]

Springer

Microchimica acta 90 (1986), S. 1-12

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ISSN: 1436-5073

Keywords: hydrates ; norfloxacin ; thermodynamically stable

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Norfloxacin, a nalidixic acid analog with antimicrobial properties, exists in different hydrated forms. Three of these crystal forms were reproducibly prepared and characterized by analytical techniques that included infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, solution microcalorimetry and pulsed nuclear-magnetic resonance spectroscopy. These studies showed that the dihydrate is the thermodynamically stable entity at ambient temperatures and humidities.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01196816

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