Publication Date:
1987-03-13
Description:
Azidothymidine and ribavirin both inhibit replication of human immunodeficiency virus in vitro and show promise of clinical utility in patients infected with this virus. In this study, the possible interactions of these drugs were examined in vitro, and a reproducible antagonism between azidothymidine and ribavirin was found to occur under a variety of experimental conditions. The mechanism responsible for this antagonism appeared to be inhibition of azidothymidine phosphorylation by ribavirin. Because similar effects may occur in vivo, clinical trials of these two drugs in combination must be performed only under carefully controlled conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogt, M W -- Hartshorn, K L -- Furman, P A -- Chou, T C -- Fyfe, J A -- Coleman, L A -- Crumpacker, C -- Schooley, R T -- Hirsch, M S -- CA 09382-04/CA/NCI NIH HHS/ -- CA 12464/CA/NCI NIH HHS/ -- CA 27569/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Mar 13;235(4794):1376-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2435003" target="_blank"〉PubMed〈/a〉
Keywords:
Cell Line
;
HIV/*drug effects/physiology
;
Humans
;
Lymphocytes/microbiology
;
Monocytes/microbiology
;
Phosphorylation
;
Phytohemagglutinins/pharmacology
;
RNA-Directed DNA Polymerase/metabolism
;
Ribavirin/*pharmacology
;
Ribonucleosides/*pharmacology
;
Thymidine/*analogs & derivatives/antagonists & inhibitors/pharmacology
;
Virus Replication/drug effects
;
Zidovudine
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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