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  • Polymer and Materials Science  (19)
  • Nuclear Structure
  • 1985-1989  (19)
  • 1
    Electronic Resource
    Electronic Resource
    Conformational analysis of cholecystokinin fragments CCK4, CCK5, and CCK6 by 1H-nmr spectroscopy and fluorescence-transfer measurements (1985)
    New York : Wiley-Blackwell
    Biopolymers 24 (1985), S. 1663-1681 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The confortmational behavior of the cholecystokinin-related fragments CCK4, CCK5, and CCK6 as determined by 1H-nmr spectroscopy in DMSO-d6 and water and fluorescence-transfer measurements in aqueous medium are greatly dependent on the ionization states of these peptides. Under netral conditions, the backbones of CCK5 and CCK6 preferentially adopted folded forms with a β-turn including the four residues Gly-Trp-Met-Asp, probably stabilized by a hydrogen bond between the CO of Gly and the NH of Phe. In these structures, possible induced by an ionic interaction between the carboxylic group of Asp32 and the NH3+ group of the N-terminal amino acid, the lateral chains of the various residues are quite distant from each other (15-16 Å). Under acidic conditions, extended structures without interactions between side chains predominate for CCK5 and CCK6, while for CCK4, a conformational change drawing the Trp and Phe side chains in close proximity was shown by fluorescence. The conformations observed in aqueous medium at physiological pH are discussed in relation to the biological activity of these peptides.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360240903
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  • 2
    Electronic Resource
    Electronic Resource
    Study of the bisintercalation of the antitumor drug ditercalinium by 31P-nmr (1988)
    New York : Wiley-Blackwell
    Biopolymers 27 (1988), S. 957-968 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bisintercalation of ditercalinium, a potent antitumoral 7H-pyriodo[4,3-c]carbazole rigid dimer, into the self-complementary tetranucleotides d(CpGpCpG)2, d(m5CpGpm5CpG) and the self-complementary hexanucleotide d(CpGpApTpCpG)2 was investigated by 162-MHz 31P-nmr. The slow exchange, on the nmr time scale, observed between the free and complexed nucleotides allows identification of the phosphorus signals in the complexes through two-dimensional chemical exchange spectroscopy. Differences in 31P chemical shifts upon intercalation are discussed in relation to the complex geometry and nature of the drug.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360270606
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  • 3
    Electronic Resource
    Electronic Resource
    1H-nmr studies of a monointercalating drug into a d[CpGpCpG]2 minihelix (1987)
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. 981-1000 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The structure of the complex formed between the 7H-pyridocarbazole monomer [{(2-piperidyl)-2,1-ethane-yl} {10-methoxy-7H-pyrido[4,3-c]carbazolium} dimethane sulfonate] and the autocom-plementary tetranucleotide d(CpGpCpG)2 in aqueous solution is analyzed by 270-MHz and 400-MHz 1H-nmr. The strong upfield shifts observed on most aromatic resonances of both the drug and the nucleotide are interpreted as the result of intercalation of the 7H-pyridocarbazole monomer in the base-paired minihelix of d(CpGpCpG). The observation of intermolecular negative nuclear Overhauser effects induced in some drug resonances by irradiation of sugar protons confirms this conclusion. A privileged orientation of the drug in the intercalation site with the quaternizing ethyl piperidine chain protruding in the major groove is proposed.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360260702
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of impurities on emulsion polymerization: Case II kinetics (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 35 (1988), S. 2009-2021 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The effects of water-soluble and monomer-soluble impurities on the kinetics of emulsion polymerization of monomers following Case II kinetics (e.g., styrene) are investigated. Experimental studies reveal that impurities can have an appreciable effect on both polymer particle nucleation and growth. These effects are shown to be well predicted by a mathematical model.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1988.070350803
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  • 5
    Electronic Resource
    Electronic Resource
    An investigation of the emulsion terpolymerization of 2-ethylhexylacrylate-vinyl acetate-acrylic acid (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 35 (1988), S. 1409-1420 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An investigation of the emulsion polymerization of 2-ethylhexylacrylate (EHA) - vinyl acetate (VAc) - acrylic acid (AA) has been done. It was found that the polymerization rate depends on the AA level and that particle nucleation occurs throughout the entire conversion range. At the 5% AA level, there is significant coagulation. The number of particles depends on the balance between nucleation and coagulation. Addition of a small amount of water-soluble comonomer has no significant effect on the course of polymerization, but the viscosity of the latex can increase significantly. The dependence of latex viscosity on pH on neutralization has been studied. The maximum viscosity reached on neutralization depends on the acrylic acid level and the semibatch policy used in the latex synthesis. Addition of salt is a simple and effective way to control viscosity buildup during neutralization.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1988.070350601
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  • 6
    Electronic Resource
    Electronic Resource
    Bisintercalation of ditercalinium into a d[CpGpCpG]2 minihelix: Structure and dynamics aspects - a 400-MHz 1H-nmr study (1987)
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. 1001-1033 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The structure of the complex formed in aqueous solution at pH 5.5 between ditercalinium, a potent antitumoral 7H-pyrido[4,3-c]carbazole rigid dimer, and the self-complementary tetranucleotide d[CpGpCpG], was investigated by 400-MHz 1H-nmr. For a 1:2.5 drug-to-helix ratio, the dimer was only found in bound form, whereas free and complexed tetranucleotide were in slow exchange. This allowed unambiguous assignment of the protons in the complex through exchange polarization transfer measurements. The tetranucleotide existed as a right-handed double helix in the complex. The strong upfield shifts measured on most aromatic protons on both drug and nucleobases as well as on DNA imino protons were consistent with bisintercalation of the dimer. According to the negative nuclear Overhauser effects generated to protons on the convex edge of the bound drug rings by saturation of sugar protons, it was concluded that ditercalinium was intercalated with its rigid bis-ethyl bispiperidine spacer fitting the major groove of the helix. Difference in antitumor activity of various pyridocarbazole dimers is discussed in relation to the binding kinetics and the complex geometry determined in this study.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360260703
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  • 7
    Electronic Resource
    Electronic Resource
    1H-nmr studies of a monointercalating drug into a d(CpGpApTpCpG)2 minihelix (1989)
    New York : Wiley-Blackwell
    Biopolymers 28 (1989), S. 2097-2113 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The structure of the complex formed between the 7H-pyridocarbazole monomer [{(2-piperidyl)-2,1-ethane-y1} {10-methoxy-7H-pyrido[4,3-c]carbazolium} dimethane sulfonate] and the autocomplementary hexanucleotide d(CpGpApTpCpG)2 in aqueous solution is analyzed by 270- and 400-MHz 1H-nmr. The large upfield shifts observed for both the drug and the self-complementary hexanucleotide protons provide evidence for intercalated complexes. The observation of intermolecular nuclear Overhauser effects between drug and the hexanucleotide protons gives a privileged orientation of the durg in the intercalation site with the quaternarizing ethyl piperidine chain protruding in the major groove. Moreover, the data suggest an intercalation based on the neighbor exclusion site principle in the three alternating sequences.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360281206
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  • 8
    Electronic Resource
    Electronic Resource
    Bisintercalation of ditercalinium into a d(CpGpApTpCpG)2 minihelix: A 1H- and 31P-NMR study (1989)
    New York : Wiley-Blackwell
    Biopolymers 28 (1989), S. 2115-2142 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The structure of the complex formed in aqueous solution between ditercalinium, a bisintercalating drug, and the self-complementary hexanucleotide d(CpGpApTpCpG)2 is investigated by 400-MHz 1H-nmr and 162-MHz 31P-nmr. Whatever the drug to thlix ratio, ditercaliniun occurred in the bound form, whereas free and complexed hexanucleotide and are in slow exchange. This allows unambiguous resonance assignm, ent through two-dimensional chemical exvhange experiments. The strong upfield shifts measured on most aromatic protons on both drug and bases as well as on DNA imino protons are consistent with bisintercalation of the dimer. Nuclear Overhauser effects observed between drug and nucleeotide protons give a defined geometry for complexation, and suggest a DNA conformational change upon drug binding.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360281207
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  • 9
    Electronic Resource
    Electronic Resource
    Conformational behavior of cyclic CCK-related peptides determined by 400-MHz 1H-nmr: Relationships with affinity and selectivity for brain receptors (1989)
    New York : Wiley-Blackwell
    Biopolymers 28 (1989), S. 69-79 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The conformational study of a homogenous series of cyclic analogues of CCK8, selective for central receptors, such as Boc- X-Tyr(SO3H)-Nle-D-Lys-Trp-Nle-Asp-Phe-NH2, where X = L-Glu, D-Glu, or γ-D-Glu, was performed by 400-MHz 1H-nmr. The regular increase in affinity for central receptors when going from [L-Glu] to [γ-D-Glu] is correlated to (a) an enhancement in internal flexibility of the cyclic moiety, (b) an external orientation of the tyrosine side chain, and (c) a restructuring of the C-terminal part of the peptide. All these results could permit a modeling of biologically active conformation of CCK8 for both receptors types to be performed.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360280110
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  • 10
    Electronic Resource
    Electronic Resource
    Displacements of precious and nonprecious dental bridges utilizing endosseous implants as distal abutments (1986)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 785-797 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An investigation was conducted to establish qualitative trends regarding the relative displacements exhibited by the distal and mesial abutments in a five-unit fixed dental bridge as a function of bridge material and implant design utilized in the distal abutment site. Both Au and Ni-based bridge systems utilizing double, natural-tooth mesial abutments and three types of distal abutments (natural second molar, blade dental implant, and hollow-basket implant) were tested on a dried human mandible and subjected to a controlled force applied distally. Dial gauges were positioned around each abutment site bilaterally to provide displacement data in the x (mesial/distal), y(buccal/lingual), and z(occlusal/gingival) directions. The results indicate some significant differences exist in the displacement profiles exhibited by the bridge systems as a function of both bridge material and abutment type.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820200610
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