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  • 1
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    HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-04-01
    Description: Characterization of the host immune response to human immunodeficiency virus type 1 (HIV-1) is critical to the rational design of an effective AIDS vaccine. In this study, cytotoxic T lymphocytes (CTL) specific for HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) were found in blood samples from HIV-1-infected individuals. CTL targets were prepared by immortalizing B cells from ten seropositive and six seronegative individuals, and then infecting these cells with recombinant vaccinia viruses containing HIV-1 genes. CTL directed against autologous B lymphoblasts expressing HIV-1 reverse transcriptase were detected in fresh blood samples from eight HIV-1 seropositive subjects, but in no seronegative controls. The effector cells were identified as major histocompatibility complex-restricted CD3+CD8+ lymphocytes. Because the HIV-1 pol gene is highly conserved among different isolates and generates both humoral and cellular immune responses, it bears consideration for inclusion in a candidate AIDS vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, B D -- Flexner, C -- Paradis, T J -- Fuller, T C -- Hirsch, M S -- Schooley, R T -- Moss, B -- CA37461/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 1;240(4848):64-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2451288" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; DNA, Recombinant ; Genes, Viral ; HIV/*enzymology/genetics ; HIV Seropositivity ; HLA Antigens/immunology ; Humans ; RNA-Directed DNA Polymerase/*immunology ; T-Lymphocytes, Cytotoxic/*immunology ; Vaccinia virus/genetics/immunology ; Viral Vaccines/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Ribavirin antagonizes the effect of azidothymidine on HIV replication (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-03-13
    Description: Azidothymidine and ribavirin both inhibit replication of human immunodeficiency virus in vitro and show promise of clinical utility in patients infected with this virus. In this study, the possible interactions of these drugs were examined in vitro, and a reproducible antagonism between azidothymidine and ribavirin was found to occur under a variety of experimental conditions. The mechanism responsible for this antagonism appeared to be inhibition of azidothymidine phosphorylation by ribavirin. Because similar effects may occur in vivo, clinical trials of these two drugs in combination must be performed only under carefully controlled conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogt, M W -- Hartshorn, K L -- Furman, P A -- Chou, T C -- Fyfe, J A -- Coleman, L A -- Crumpacker, C -- Schooley, R T -- Hirsch, M S -- CA 09382-04/CA/NCI NIH HHS/ -- CA 12464/CA/NCI NIH HHS/ -- CA 27569/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Mar 13;235(4794):1376-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2435003" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; HIV/*drug effects/physiology ; Humans ; Lymphocytes/microbiology ; Monocytes/microbiology ; Phosphorylation ; Phytohemagglutinins/pharmacology ; RNA-Directed DNA Polymerase/metabolism ; Ribavirin/*pharmacology ; Ribonucleosides/*pharmacology ; Thymidine/*analogs & derivatives/antagonists & inhibitors/pharmacology ; Virus Replication/drug effects ; Zidovudine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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