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  • 1
    Electronic Resource
    Electronic Resource
    K-Permeabilized human red cells lose an alkaline, hypertonic fluid containing excess K over diffusible anions (1987)
    Springer
    The journal of membrane biology 96 (1987), S. 235-241 
    Details
    ISSN: 1432-1424
    Keywords: K permeability ; volume regulation ; pH regulation ; red cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Experiments were performed to test specific predictions of an integrated red cell model developed by Lew and Bookchin [Lew, V.L., Bookchin, R.M.J. Membrane Biol. 92:57–74 (1986)], that K-permeabilized human red cells suspended in low-K media would dehydrate and lose an alkaline, hypertonic fluid with excess K over accompanying anions, and that cell dehydration would precede medium alkalinization. Red cells were suspended at about 30% hematocrit in an initially K-free Na-saline and permeabilized to K by the addition of valinomycin. The results showed that by the time a quasi-steady state had been reached the cells had lost the equivalent of a hypertonic fluid containing about 180 mM KCl (SCN) and 10 mM KOH, and that cell dehydration did precede alkalinization of the medium, in good agreement with the theoretical predictions. Since these experiments critically test the interaction between transport, pH and volume regulatory functions in the human red cell, the observed agreement validates the basic assumptions and structure of the integrated model. The functional implications of these results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01869305
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Volume, pH, and ion-content regulation in human red cells: Analysis of transient behavior with an integrated model (1986)
    Springer
    The journal of membrane biology 92 (1986), S. 57-74 
    Details
    ISSN: 1432-1424
    Keywords: red cells ; volume regulation ; pH regulation ; ion transport ; sickle-cell anemia red cells ; Ca2+-sensitive K channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary A basic mathematical model of human red cells is presented which integrates the charge and nonideal osmotic behavior of hemoglobin and of other impermeant cell solutes with the ion transport properties of the red cell membrane. The computing strategy was designed to predict the behavior of all measurable variables in time in ways that optimize comparison with experimentally determined behavior. The need and applications of such a model are illustrated in three separate examples covering different areas of experimentation in the physiology and pathophysiology of red cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01869016
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  • 3
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    Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-12
    Description: While much information exists about the structure and function of the clonally distributed T cell receptor (TCR) alpha beta heterodimer, little is known about the gamma protein, the product of a third rearranging TCR gene. An antiserum to a carboxyl-terminal peptide common to several of the murine gamma chain constant regions and a monoclonal antibody to the murine T3 complex were used to identify products of this TCR gene family in a subpopulation of Lyt2-, L3T4- thymocytes. This subpopulation does not express TCR alpha or full-length TCR beta messenger RNA. The gamma chain is a 35-kilodalton (kD) protein that is disulfide-bonded to a 45-kD partner and is associated with the T3 complex. Analysis of the glycosylation pattern of this thymic gamma chain revealed that the major variable region gamma (V gamma) gene transcribed in activated peripheral T cells is absent from this subpopulation. The cells that bear this second T cell receptor may therefore represent a distinct lineage differentiating within the thymus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lew, A M -- Pardoll, D M -- Maloy, W L -- Fowlkes, B J -- Kruisbeek, A -- Cheng, S F -- Germain, R N -- Bluestone, J A -- Schwartz, R H -- Coligan, J E -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1401-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3787252" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Disulfides/analysis ; Electrophoresis, Polyacrylamide Gel ; Glycosylation ; Macromolecular Substances ; Mice ; Molecular Weight ; RNA, Messenger/metabolism ; Receptors, Antigen, T-Cell/*biosynthesis/genetics ; Structure-Activity Relationship ; Thymus Gland/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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