Publication Date:
1985-11-01
Description:
The mechanism of cellular transformation by the human T-cell leukemia viruses (HTLV) is thought to involve a novel gene known as the x gene. This gene is essential for HTLV replication and acts by enhancing transcription from the HTLV long terminal repeat. The HTLV x gene product may also cause aberrant transcription of normal cellular genes, resulting in transformation of the infected cells. Although there is no evidence as yet for such a mechanism, it was shown that the HTLV-II x gene product can activate transcription from adenovirus E1A-dependent early promoters and therefore has the potential to activate cellular genes. It was also shown that the adenovirus and herpes pseudorabies immediate early proteins activate expression from the HTLV-I and HTLV-II long terminal repeats, though at lower levels than with the x gene product. These findings indicate possible common mechanisms of action for transcription-regulatory genes of distinct viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, I S -- Cann, A J -- Shah, N P -- Gaynor, R B -- CA 16042/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- CA 38597/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):570-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996140" target="_blank"〉PubMed〈/a〉
Keywords:
Adenoviridae/*genetics
;
Cell Transformation, Viral
;
Deltaretrovirus/*genetics
;
Endonucleases/metabolism
;
HeLa Cells
;
Herpesvirus 4, Human
;
Humans
;
Operon
;
Repetitive Sequences, Nucleic Acid
;
Single-Strand Specific DNA and RNA Endonucleases
;
Transcription, Genetic/*drug effects
;
Transfection
;
Viral Proteins/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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