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  • Articles  (2)
  • Cell & Developmental Biology  (1)
  • Polymer and Materials Science  (1)
  • 1985-1989  (2)
  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 9 (1988), S. 48-59 
    ISSN: 0886-1544
    Keywords: axon ; growth cone ; retraction ; taxol ; slow transport ; axonal transport ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Axons in tissue culture retract and shorten if their tips are detached from the substrate. The shortening reaction of the axon involves contractile forces that also arise during normal axonal motility, elongation, and retraction. We studied shortening in axonal segments isolated from their parent axons by transecting the axon between the growth cone and the most distal point of adhesion to the substrate. Within 15-20 minutes after transection, an isolated axonal segment shortened and pulled its tail end toward the growth cone. During the shortening process, long sinusoidal bends arose along the axon. The identical shortening reaction occurs without transection, when the axon tip is detached from the substrate. Pharmacological studies with inhibitors of glycolysis indicate that the shortening mechanisms utilize metabolic energy, presumably ATP. The rate of sinusoidal shortening is similar to both the rate of polymer translocation in the axon by slow axonal transport and the rate of normal axonal elongation. Taxol inhibits the shortening reaction with a similar dose dependence to its inhibition of axonal growth. Together, all these observations suggest that the same basic intracellular motility mechanisms are involved in normal axonal growth, in slow axonal transport, and in the shortening reaction: the intracellular dynamic system that utilizes ATP to generate longitudinal movements of polymers within the axon may be the same mechanism underlying both the retraction and the elongation of the axon.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 36 (1985), S. 645-648 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Untersucht wurden 1H-FID- und MW4-Spektren vom mit Ethylendimethacrylat und Divinylbenzen vernetztem und mit CCl4, CDCl3 und Benzen gequollenem Polystyren. Die mit Hilfe von Vielimpulscyclen erreichbaren Linienverschmälerungen werden diskutiert und mit denen der MAR-Technik verglichen. Die Temperaturabhängigkeit der effektiven Relaxationszeit T2eff spiegelt die Dynamik lokaler Segmentprozesse wider.
    Notes: 1H-FID and MW4-pulse spectra of polystyrene crosslinked with ethylene dimethacrylate or divinylbenzene and swollen in CCl4, CDCl3 or benzene, are measured. Line-narrowing effects of multiple-pulse sequences are discussed and compared with those of the MAR-technique. The temperature dependence of the effective relaxation time T2eff reflects the dynamics of local segmental processes.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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