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  • Nucleic Acid Hybridization  (5)
  • Analytical Chemistry and Spectroscopy  (3)
  • STRUCTURAL MECHANICS
  • 1985-1989  (9)
  • 1
    Electronic Resource
    Electronic Resource
    Fast atom bombardment mass spectra of O-isopropyl oligodeoxyribonucleotide triesters (1985)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 20 (1985), S. 781-783 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The positive and negative fast atom bombardment (FAB) mass spectra of representative dimeric O-isopropyl oligodeoxyribonucleotide triesters were recorded and examined. Features found to be shared among the FAB mass spectra of these compounds yielded important information regarding molecular weight, nucleobase composition and nucleotide sequence.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210201216
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Carbon-13 NMR spectra of 1,3-dioxolanes. IIFor Part I see Ref. 4. - determination of α, β and γ parameters for 2- and 4-methyl groups in stereoisomeric derivatives by the pattern molecule method (1988)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 26 (1988), S. 108-110 
    Details
    ISSN: 0749-1581
    Keywords: 1,3-Dioxolane derivatives ; 13C NMR shift parameters ; Pattern molecule method ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: On the basis of the stereochemistry of the 1,3-dioxolane ring, the molecular pattern method allows the establishment of α, β and γ parameters for the 2-Me and 4-Me substituents. Values of α, β and γ additive parameters for the syn and anti 4-Me group in 2,2,4-trisubstituted-1,3-dioxolanes are proposed. The average values of the α, β and γ effects for the 2-Me and 4-Me groups obtained by the molecular pattern method are consistent with those reported from a multiple linear regression analysis.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260260204
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Carbon-13 NMR spectra of 1,3-dioxolanes. I - new parameters for cis- and trans-4-methyl groups in 2,4-disubstituted derivatives (1986)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 24 (1986), S. 754-757 
    Details
    ISSN: 0749-1581
    Keywords: 1,3-dioxolane derivatives ; 13C NMR ; Shift parameters ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 13C NMR spectra of 24 1,3-dioxolane derivatives are reported in an attempt to propose parameters for the C-2, C-4 and C-5 shifts from the 2-Me and 4-Me substituents, based on the ring stereochemistry. These parameters are obtained from simultaneous equations, and clearly agree with those calculated by the use of pattern molecules. The calculated parameter for the C-4 shift due to a 2-Me group differs notably from that proposed by other workers.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260240904
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    Paper (German National Licenses)
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  • 4
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    Infectious mutants of HTLV-III with changes in the 3' region and markedly reduced cytopathic effects (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-08
    Description: A variant of human T-lymphotropic virus type III (HTLV-III) is described that replicates but does not kill normal human T cells in vitro. This variant, designated X10-1, was derived from the genome of a cytopathic HTLV-III clone (pHXB2D) by excision of a 200-base pair segment in the 3' region of the virus, spanning the env and 3'-orf genes. Comparable variants with 55 to 109 base pairs deleted exclusively in 3'-orf produced, in contrast, virus that was extremely cytopathic. On the basis of these findings it is concluded that the 3'-orf gene is not required for cytopathogenicity or replication of HTLV-III. In addition, the results suggest that virus replication and cytotoxicity are not intrinsically coupled. Furthermore, since clone X10-1 retains the ability to trans-activate genes linked to the viral long terminal repeats, trans-activation per se is not responsible for T-cell killing by HTLV-III. These results also raise the possibility that the carboxyl terminus of the envelope gene of HTLV-III has a direct role in T-cell killing by this virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fisher, A G -- Ratner, L -- Mitsuya, H -- Marselle, L M -- Harper, M E -- Broder, S -- Gallo, R C -- Wong-Staal, F -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):655-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3014663" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Cloning, Molecular ; Deltaretrovirus/*genetics/pathogenicity ; Humans ; Mutation ; Nucleic Acid Hybridization ; RNA, Viral/genetics ; T-Lymphocytes/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 5
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    The role of mononuclear phagocytes in HTLV-III/LAV infection (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-11
    Description: Cells with properties characteristic of mononuclear phagocytes were evaluated for infectivity with five different isolates of the AIDS virus, HTLV-III/LAV. Mononuclear phagocytes cultured from brain and lung tissues of AIDS patients harbored the virus. In vitro-infected macrophages from the peripheral blood, bone marrow, or cord blood of healthy donors produced large quantities of virus. Virus production persisted for at least 40 days and was not dependent on host cell proliferation. Giant multinucleated cells were frequently observed in the macrophage cultures and numerous virus particles, often located within vacuole-like structures, were present in infected cells. The different virus isolates were compared for their ability to infect macrophages and T cells. Isolates from lung- and brain-derived macrophages had a significantly higher ability to infect macrophages than T cells. In contrast, the prototype HTLV-III beta showed a 10,000-fold lower ability to infect macrophages than T cells and virus production was one-tenth that in macrophage cultures infected with other isolates, indicating that a particular variant of HTLV-III/LAV may have a preferential tropism for macrophages or T cells. These results suggest that mononuclear phagocytes may serve as primary targets for infection and agents for virus dissemination and that these virus-infected cells may play a role in the pathogenesis of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gartner, S -- Markovits, P -- Markovitz, D M -- Kaplan, M H -- Gallo, R C -- Popovic, M -- New York, N.Y. -- Science. 1986 Jul 11;233(4760):215-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3014648" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology ; Brain/cytology ; Cells, Cultured ; Child ; DNA, Viral/genetics ; Deltaretrovirus/isolation & purification ; Humans ; Lung/cytology ; Macrophages/physiology ; Nucleic Acid Hybridization ; Phagocytes/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Genomic analysis of the human B-lymphotropic virus (HBLV) (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-31
    Description: The human B-lymphotropic virus (HBLV) has a double-stranded DNA genome of greater than 110 kilobase pairs, which is consistent with its morphological classification as a herpesvirus. A 9000-base pair cloned probe of HBLV detected specific sequences in DNA and RNA of infected cells but did not hybridize to the genomic DNA of other human herpesviruses including the Epstein-Barr virus, human cytomegalovirus, herpes simplex type I, and varicella-zoster virus. Conversely, while probes obtained from each of the known human herpesvirus readily detected the homologous viral DNA, they did not hybridize to genomic HBLV DNA. This evidence, in addition to serological and morphological distinctions and the biological effects of this virus demonstrate that HBLV is a novel human herpesvirus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Josephs, S F -- Salahuddin, S Z -- Ablashi, D V -- Schachter, F -- Wong-Staal, F -- Gallo, R C -- New York, N.Y. -- Science. 1986 Oct 31;234(4776):601-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3020691" target="_blank"〉PubMed〈/a〉
    Keywords: Cytomegalovirus/genetics ; DNA, Viral/genetics ; Herpesviridae/*genetics ; Herpesvirus 2, Saimiriine/genetics ; Herpesvirus 3, Human/genetics ; Herpesvirus 4, Human/genetics ; Humans ; Nucleic Acid Hybridization ; Simplexvirus/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-20
    Description: In a study of genetic variation in the AIDS virus, HTLV-III/LAV, sequential virus isolates from persistently infected individuals were examined by Southern blot genomic analysis, molecular cloning, and nucleotide sequencing. Four to six virus isolates were obtained from each of three individuals over a 1-year or 2-year period. Changes were detected throughout the viral genomes and consisted of isolated and clustered nucleotide point mutations as well as short deletions or insertions. Results from genomic restriction mapping and nucleotide sequence comparisons indicated that viruses isolated sequentially had evolved in parallel from a common progenitor virus. The rate of evolution of HTLV-III/LAV was estimated to be at least 10(-3) nucleotide substitutions per site per year for the env gene and 10(-4) for the gag gene, values a millionfold greater than for most DNA genomes. Despite this relatively rapid rate of sequence divergence, virus isolates from any one patient were all much more related to each other than to viruses from other individuals. In view of the substantial heterogeneity among most independent HTLV-III/LAV isolates, the repeated isolation from a given individual of only highly related viruses raises the possibility that some type of interference mechanism may prevent simultaneous infection by more than one major genotypic form of the virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hahn, B H -- Shaw, G M -- Taylor, M E -- Redfield, R R -- Markham, P D -- Salahuddin, S Z -- Wong-Staal, F -- Gallo, R C -- Parks, E S -- Parks, W P -- AI 23616-01/AI/NIAID NIH HHS/ -- AI 23854-01/AI/NIAID NIH HHS/ -- P30 CA 13148/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1548-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3012778" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Amino Acid Sequence ; Base Sequence ; Chromosome Deletion ; DNA Restriction Enzymes ; DNA Transposable Elements ; Deltaretrovirus/*genetics/isolation & purification ; *Genetic Variation ; Humans ; Mutation ; Nucleic Acid Hybridization ; Risk
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-11
    Description: A study was conducted of the genetic relation between human T-cell lymphotropic retroviruses and visna virus. The human T-cell lymphotropic viruses include those associated with T-cell malignancies (HTLV-I and HTLV-II) as well as the etiologic agent of the acquired immune deficiency syndrome (HTLV-III). Visna virus, a slowly replicating and pathogenic but nononcogenic retrovirus of sheep, is a member of the subfamily Lentivirinae. Results obtained by molecular hybridization and heteroduplex analysis indicated that a greater extent of nucleotide sequence homology exists between HTLV-III and visna virus than between HTLV-III and any of the other viruses. The homology observed under conditions of low stringency spanned the entire genome, but was strongest in the gag/pol region. The morphogenesis and fine structure of HTLV-III and visna virus also demonstrated striking similarities. The data provide strong evidence for a close taxonomic and thus evolutionary relation between HTLV-III and the Lentivirinae subfamily.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonda, M A -- Wong-Staal, F -- Gallo, R C -- Clements, J E -- Narayan, O -- Gilden, R V -- N01-CO-23910/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Jan 11;227(4683):173-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2981428" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Deltaretrovirus/*genetics/ultrastructure ; Genes, Viral ; Microscopy, Electron ; Nucleic Acid Heteroduplexes ; Nucleic Acid Hybridization ; RNA, Viral ; Visna-maedi virus/*genetics/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    A New NASTRAN Capability for Data Reduction (1985)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: A new module, MODB, for the data reduction of NASTRAN results is described. NASTRAN analysis results can be filtered and sorted for minimum/maximum values and the printed output resulting from large NASTRAN runs can be limited based on a number of available user options. The sorting is done on stresses, forces and vector quantities like displacements, velocity, and acceleration. The module can be accessed via DMAP alters to existing rigid formats, and has been used on a large number of statics and dynamics problems resulting in considerable savings in cost, time, and the amount of printing.
    Keywords: STRUCTURAL MECHANICS
    Type: COSMIC 13th NASTRAN (R) Users' Colloq.; p 177-187
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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