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  • 1
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    Calcium antagonist receptors in cardiomyopathic hamster: selective increases in heart, muscle, brain (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-25
    Description: The Syrian cardiomyopathic hamster has a hereditary disease in which a progressive myocardial necrosis mimics human forms of cardiac hypertrophy. Lesions are associated with calcium overload and can be prevented with the calcium antagonist verapamil. Numbers of receptor binding sites for calcium antagonists in heart, brain, skeletal muscle, and smooth muscle were markedly increased in cardiomyopathic hamsters. The uptake of calcium-45 into brain synaptosomes was also increased in cardiomyopathic hamsters. The increase in calcium antagonist receptors and related voltage-sensitive calcium channels may be involved in the pathogenesis of this cardiomyopathy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wagner, J A -- Reynolds, I J -- Weisman, H F -- Dudeck, P -- Weisfeldt, M L -- Snyder, S H -- HL-17655/HL/NHLBI NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):515-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3008330" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism/physiopathology ; *Brain Chemistry ; Calcium/metabolism ; Calcium Channels ; Cardiomyopathy, Hypertrophic/*physiopathology ; Cricetinae ; Disease Models, Animal ; Female ; Heart/physiopathology ; Male ; Mesocricetus ; Muscle, Smooth/analysis/metabolism ; Muscles/*analysis/metabolism/physiopathology ; Myocardium/*analysis/metabolism ; Nifedipine/analogs & derivatives/metabolism ; Nitrendipine ; Receptors, Nicotinic/*analysis/metabolism/physiology ; Synaptosomes/metabolism ; Verapamil/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Virus-induced increases in plasma corticosterone (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunn, A J -- Powell, M L -- Gaskin, J M -- MH25486/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1987 Dec 4;238(4832):1423-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, College of Medicine, University of Florida, Gainesville 32610.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3685987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corticosterone/*blood ; Female ; Hypophysectomy ; Lymphocytes/physiology ; Male ; Mice ; Mice, Inbred Strains ; Models, Biological ; Newcastle Disease/*blood ; Pituitary-Adrenal System/*physiopathology ; Postoperative Complications/blood ; Stress, Physiological/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-02-13
    Description: A highly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus. A number of cats in one pen had died and several had an immunodeficiency-like syndrome. Only 1 of 18 normal cats in the cattery showed serologic evidence of infection with this new virus, whereas 10 of 25 cats with signs of ill health were seropositive for the virus. Tentatively designated feline T-lymphotropic lentivirus, this new feline retrovirus appears to be antigenically distinct from human immunodeficiency virus. There is no evidence for cat-to-human transmission of the agent. Kittens experimentally infected by way of blood or plasma from naturally infected animals developed generalized lymphadenopathy several weeks later, became transiently febrile and leukopenic, and continued to show a generalized lymphadenopathy 5 months after infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, N C -- Ho, E W -- Brown, M L -- Yamamoto, J K -- CA-39016-02/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Feb 13;235(4790):790-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3643650" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/analysis ; Cat Diseases/*microbiology ; Cats/*microbiology ; Female ; HIV/immunology ; Immunologic Deficiency Syndromes/microbiology/*veterinary ; Lymphocytes/ultrastructure ; Male ; Microscopy, Electron ; Retroviridae/immunology/*isolation & purification/ultrastructure ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-02-08
    Description: The nonsteroidal anti-inflammatory drug, flurbiprofen, a potent cyclooxygenase inhibitor, significantly decreases the resorption of alveolar bone in naturally occurring chronic destructive periodontal disease in beagles. This observation indicates that arachidonic acid metabolites are important in the alveolar bone loss of periodontitis and suggests a use for flurbiprofen in the management of bone resorption disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, R C -- Jeffcoat, M K -- Kaplan, M L -- Goldhaber, P -- Johnson, H G -- Wechter, W J -- New York, N.Y. -- Science. 1985 Feb 8;227(4687):640-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969553" target="_blank"〉PubMed〈/a〉
    Keywords: Alveolar Process/drug effects/physiology ; Animals ; Bone Resorption/*drug effects ; Dogs ; Female ; Flurbiprofen/*pharmacology/therapeutic use ; Humans ; Periodontal Diseases/drug therapy ; Propionates/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Huntington's disease: two families with differing clinical features show linkage to the G8 probe (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: To test the hypothesis that interfamily variability in Huntington's Disease (HD) is due to mutation at different loci, linkage analysis was undertaken in two large HD kindreds that differed in ethnicity, age-at-onset, and neurologic and psychiatric features. Both families showed linkage of the HD locus to the G8 probe. Several recombinants were documented in each family, and the best estimate of the recombination fraction for the two families was 6 percent with a 95 percent confidence interval of 0 to 12 percent. Although the data support the existence of a single HD locus, use of the G8 probe for presymptomatic testing in these kindreds would have resulted in a 12 percent error rate in genotype assignment at the HD locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Folstein, S E -- Phillips, J A 3rd -- Meyers, D A -- Chase, G A -- Abbott, M H -- Franz, M L -- Waber, P G -- Kazazian, H H Jr -- Conneally, P M -- Hobbs, W -- AM 13983/AM/NIADDK NIH HHS/ -- NS 16367/NS/NINDS NIH HHS/ -- NS 16375/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):776-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992086" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosomes, Human, 4-5 ; DNA Restriction Enzymes ; DNA, Recombinant ; Female ; Genetic Linkage ; Humans ; Huntington Disease/*genetics ; Male ; Pedigree ; Recombination, Genetic ; Risk
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Parametric instabilities of the circularly polarized Alfven waves including dispersion (1986)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: A class of parametric instabilities of large-amplitude, circularly polarized Alfven waves is considered in which finite frequency (dispersive) effects are included. The dispersion equation governing the instabilities is a sixth-order polynomial which is solved numerically. As a function of K identically equal to k/k-sub-0 (where k-sub-0 and k are the wave number of the 'pump' wave and unstable sound wave, respectively), there are three regionals of instability: a modulation instability at K less than 1, a decay instability at K greater than 1, and a relatively weak and narrow instability at K close to squared divided by v-sub-A squared (where c-sub-s and v-sub-A are the sound and Alfven speeds respectively), the modulational instability occurs when beta is less than 1 (more than 1) for left-hand (right-hand) pump waves, in agreement with the previous results of Sakai and Sonnerup (1983). The growth rate of the decay instability of left-hand waves is greater than the modulational instability at all values of beta. Applications to large-amplitude wave observed in the solar wind, in computer simulations, and in the vicinity of planetary and interplanetary collisionless shocks are discussed.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 91; 5617-562
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  • 7
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    Spectral signatures of jumps and turbulence in interplanetary speed and magnetic field data (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: It is shown here that, consistent with a suggestion of Burlaga and Mish (1987), the f exp -2 spectra in the magnitudes of the magnetic and velocity fields in the solar wind result from jumps due to various rapid changes in the time series for these quantities. If these jumps are removed from the data, the spectra of the resulting 'difference' time series have the f exp -5/3 form. It is concluded that f exp -2 spectra in these magnitudes arise from phase coherent structures that can be distinguished clearly from incoherent turbulent fluctuations.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 92; 10
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  • 8
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    Numerical simulation of the generation of turbulence from cometary ion pick-up (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Observations of magnetic field fluctuations near Comet Halley have revealed a rapid development of a Kolmogoroff-like turbulence spectrum extending from below 0.01 Hz to above 0.1 Hz. Spectra obtained far from the comet have a strong peak in power near the Doppler-shifted ion-cyclotron frequency of singly ionized water. Closer to the comet, the spectrum at higher frequencies is enhanced in power level over the background solar wind spectrum by approximately an order of magnitude. The equations of incompressible MHD are solved using a two-dimensional 256 x 256 mode spectral method code to simulate this spectral evolution as an inertial range turbulent cascade. The initial conditions contained a constant magnetic field and a single coherent wave mode at a low wave number. The solar wind turbulence was modeled by a background noise spectrum having a Kolmogoroff spectral index. The coherent mode decayed into an inertial range spectrum with Kolmogoroff slope within a few eddy-turnover times. Both the time scale and the increase in power level of the turbulence seen in the simulation are in accord with the Giotto observations.
    Keywords: ASTROPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 14; 860-863
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  • 9
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    Spectral characteristics of low-frequency plasma turbulence upstream of Comet P/Halley (1989)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Two upstream regions have been identified in Giotto spacecraft magnetic field and plasma measurements subjected to cross-spectral analyses, in order to determine this cometary environment's low-frequency plasma turbulence spectral characteristics. One region's solar wind magnetic field was approximately parallel, and the other's perpendicular, to the solar wind flow velocity direction. Additional divergences relate to the regions having magnetic field lines that are either connected or disconnected to the cometary bow shock wave in either the quasi-parallel or quasi-perpendicular regions.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 94; 37-48
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  • 10
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    Notes on lunar ilmenite (1989)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Opaques (mostly ilmenite) make up 0 to 5 percent of highland rocks, 1 to 11 percent of low-Ti mare basalts, and 10 to 34 percent of high-Ti mare basalts (Carter 1988). Apollos 11 and 17 sampled high-Ti basalts. Apollos 12 and 14 sampled low-Ti basalts. Apollo 15 sampled a complex mixture of mare and highland material. Apollo 16 sampled mainly highland material (Taylor 1975).
    Keywords: ASTROPHYSICS
    Type: NASA Space Engineering Research Center for Utilization of Local Planetary Resources; 6 p
    Format: application/pdf
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