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  • ASTROPHYSICS  (778)
  • SPACE RADIATION  (257)
  • Biochemistry and Biotechnology  (253)
  • 1985-1989  (1,288)
  • 1
    Electronic Resource
    Electronic Resource
    Large-scale production of monoclonal antibodies in suspension culture (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 32 (1988), S. 993-1000 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Monoclonal antibodies are being manufactured for clinical trials in suspension culture at the 1300-L scale. Suspension culture offers some advantages relative to high-density mammalian cell culture methods; in particular, the ability to closely monitor the behavior of cells in a homogeneous environment. Computer control and on-line mass spectrography of exit gases provide instantaneous information about the culture metabolic activity. Air sparging and agitation by marine impeller provide aeration sufficient to maintain a constant dissolved oxygen tension at cell concentrations up to 5.0 × 106 cells/mL without causing apparent cell damage.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260320807
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A microfibril-generating factor from the cellulase of Trichoderma reesei (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 31 (1988), S. 321-327 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A combination of ionic strength reduction and diafiltration of Trichoderma reesei cellulate complex through a hollow fiber apparatus of 5000 molecular weight (MW) cutoff and subsequent passage of filtrate over a Spherogel-TSK 3000-SW column provided extracts that had the ability to generate microfibrils in filter paper and to disrupt filter paper and corn leaf tissue. Milligram quantities of material obtained from these extracts released small amounts of soluble carbohydrate from filter paper, required ferric iron for increased activity, and contained amino acids. Short fiber formation and disruption of filter paper during interaction with these extracts was enhanced by prior acid treatment and eliminated by prior base treatment. The amount of soluble carbohydrate hydrolyzed in 24 h from filter paper by whole cellulase complex was not changed by first disrupting the substrate with the extracts.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260310407
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  • 3
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    Occultation studies of the solar system (1986)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Determination of the size, shape, mean density, and albedo of Ceres was made. Predictions for 133 occultations of bright stars occurring in 1986 and 1987 were completed and published, as have predictions of occultations of stars by Comet Halley. Twenty-nine mutual events involving Galilean satellites were observed at Flagstaff in 1985.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington Reports of Planetary Astronomy, 1985; p 108-109
    Format: text
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  • 4
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    The molecular gas in the supernova remnant IC443 (1986)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Although a few highly perturbed regions characterized by gas motions with velocities larger than 20 km/s have been discovered during the last several years in the supernova remnant (SNR) IC 443, the nature of these perturbed clumps and their relationship to the quiescent molecular gas near the SNR remains unknown. In part, this is due to a lack of large-scale, high angular resolution observations. Therefore, a systematic survey of this SNR in the CO (J=1 yields 0) line has been conducted, covering a roughly 50' x 50' region spaced by 2'. The observations were made with the 14 m telescope of the Five College Radio Astronomy Observatory (FCRAO), which has a resolution of 45" and a single sideband receiver temperature of 200 K at 2.6 mm wavelength. Five new clumps were discovered, bringing the total number of known perturbed regions to eight. To study the physical structure of these clumps in more detail, more complete maps of the clumps have been made in both the CO(J=1 yields 0) and (J=2 yields 1) transitions with the FCRAO telescope. These maps show that the extent of perturbed gas in a typical clump is several arcmin, or a few pc at a distance of 1.5 kpc.
    Keywords: ASTROPHYSICS
    Type: NASA. Ames Research Center Summer School on Interstellar Processes: Abstracts of Contributed Papers; p 69-70
    Format: application/pdf
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  • 5
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    The missing bulge globular clusters in M31 - New optical candidates (1985)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: A new method to attack the question of the 'missing' globular clusters in the bulge of M31 is used. Image-processing techniques were used on 13 videocamera fields to obtain an accurate photometric census of stellar objects in M31's bulge down to a limiting B magnitude of 21. This luminosity distribution is compared with the Bahcall-Soneira model of galactic foreground stars. A statistically significant excess of bright images in the luminosity range of globular clusters at M31's distance is found. If the optical candidates considered prove to be globular clusters, they would double the number of known globular clusters in the surveyed region. The colors of a subsample of the candidates are the same as those of the known globular clusters. It is concluded that the previously observed flattening away from a de Vaucouleurs law in the radial distribution of M31 may be an observational selection effect. As an offshoot of this analysis, no evidence is found for very luminous stars in the inner bulge of M31. The lack of such stars indicates that there has not been active star formation (with a normal IMF) in the recent past. Coupled with the existence of many planetary nebulae in the bulge, this may strengthen the case for a galactic wind in M31's bulge.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 290; 140-153
    Format: text
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  • 6
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    Construction of the Soudan 2 detector (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Progress in the construction of the Soudan 2 nucleon decay detector which is being built at the Soudan iron mine in Minnesota is discussed. The expected event rate and characteristics of low energy neutrino events, muon events, multiple muon events, and other cosmic ray phenomena are discussed.
    Keywords: SPACE RADIATION
    Type: HE-6.2-5 , 19th Intern. Cosmic Ray Conf - Vol. 8; p 267-270; NASA-CP-2376-VOL-8
    Format: application/pdf
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  • 7
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    Shock chemistry in the molecular clouds associated with SNR IC 443 (1989)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Observations of several interstellar molecules toward the highly perturbed B and G clouds associated with SNR IC 443 are reported. The results suggest that hot and dense material is present in the SNR, and that shocks are present in both regions. The HCO(+) abundance is shown to be a few times greater that found in cold quiescent gas, in contradiction with previous results. The SO, CS, CN, and NH3 abundances are similar to those found in cold dark clouds.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 341; 857-866
    Format: text
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  • 8
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    Meridional plasma flow in the outer heliosphere (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Voyager 2 observations made in the outer heliosphere near 25 AU and within 2 deg of the heliographic equatorial plane show periodic variations in the meridional (North/South) flow velocities that are much more prominent than the East/West variations. An autocorrelation analysis shows that the flow variation has a period of about 25.5 days in the latter half of 1986, in approximate agreement with the solar rotation period. The results suggest that increased pressure in interaction regions remains the best candidate for the driver of the nonradial flows.
    Keywords: ASTROPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 15; 1519-152
    Format: text
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  • 9
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    On the nearest molecular clouds. II - MBM 12 and 16 (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: The paper presents echelle spectra recorded at the D lines of Na I for three stars projected on the high-latitude molecular cloud MBM 16 at l = 172 deg, b = -38 deg. The A stars HD 21142 at about 95 pc and HD 21134 at about 240 pc show strong D-line absorption at the same velocities as the CO emission observed at these positions. The distance to MBM 16 therefore is in the range of 60 to 95 pc. MBM 16 is only 11 deg away from MBM 12, previously placed by the same method at distance of about 65 pc. Consideration is given to the relationship between clouds 12 and 16 and the local hot low-density interstellar gas.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 327; 356-363
    Format: text
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  • 10
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    A molecular cloud in the local, hot interstellar medium (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Echelle spectra recorded at the D lines of Na I are reported for nine A or F stars. Lying at approximate distances ranging from 25 to 230 pc, the stars are projected on or near the high-latitude molecular cloud MBM 12 at l = 159 deg, b = -34 deg. Among a subgroup of five of these stars separated by no more than 1.2 deg on the sky, four which are located at distances d more than 70 pc show strong interstellar D line absorption near the radial velocity of the CO emission observed in this general direction. The fifth star, at roughly 60 pc, shows no detectable absorption. MBM 12 therefore probably lies at roughly 65 pc, within the local region filled primarily by very hot, low-density gas, a conclusion supported by the large internal velocity dispersion of the molecular cloud complex.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters to the Editor (ISSN 0004-637X); 306; L109-L11
    Format: text
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