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  • 61.40  (1)
  • Dysplastic naevus syndrome  (1)
  • facial cleft  (1)
  • Organic Chemistry
  • SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING
  • 1985-1989  (3)
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Keywords
Publisher
Years
Year
  • 1
    ISSN: 1432-0630
    Keywords: 61.80 ; 61.40
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Fast heavy ions produce stable defects in most dielectrica. As examples mica, Polyethylenterephtalat and Polystyrol were irradiated with Ar, Ni, Kr, Xe and U ions in an energy range from 0.5 up to 20 MeV/u. The resulting defects were investigated by neutron and x-ray small-angle scattering. The ion beam supplied by the UNILAC accelerator at GSI Darmstadt is characterized by its small emittance, the well defined mass, charge and energy of the ions and their stochastical distribution in the phase space. In scattering experiments the system of scattering centers created by these ions causes a scattered intensity distribution which strongly depends on the orientation of the sample with respect to the unscattered neutron or x-ray beam. This dependence is investigated and explained. By a mathematical model — describing form, size, and density of the average ion track — the measured intensity distribution is simulated. Based on the model, computer procedures are written, simulating the scattering experiment by varying the most important experimental and instrumental parameters and calculating the expected theoretical intensity distribution on the detector. The parameter values of this model — the maximum density difference in the track, length of the defect, and radial dimension — are determined by least square fits to the measured data. A simple description of the dependence of these parameters on the ion energy can be given in relation to the energy loss of the primary ion. It is not only possible now to predict an expected track, to calculate its volume and the number of missing atoms, but moreover to check theories of the track formation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 169-171 
    ISSN: 1420-9071
    Keywords: Dysplastic naevus syndrome ; DNA-repair ; cancer genes ; familial malignant melanoma ; monoclonal antibodies specific for UV-dimers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dysplastic naevus syndrome (DNS) is frequently observed in association with familial melanoma and xeroderma pigmentosum (XP), but the role of UV-light in the development of DNS has not been elucidated. Previous work has shown that UV-induced unscheduled DNA synthesis is associated with the early loss of antigenicity observed in immunoassays using a monoclonal antibody specific for thymine-thymine dimers. We now show that the rate of loss of antigenicity, which reflects the relative amount of bound antibody, observed during the first 60 min following 10 Jm−2 UVC irradiation is significantly reduced (p=0.02) in cultures of fibroblasts from 7 out of 8 DNS patients compared with the results from cells of a group of 30 healthy volunteers. This observation suggests an early event in excision repair is altered in the majority of DNS patients.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 151-153 
    ISSN: 1432-1041
    Keywords: pharmacogenetics ; acetylator phenotype ; congenital anomalies/-heart disease ; facial cleft ; spina bifida
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypothesis has been tested that an unusual maternal acetylator phenotype can predispose to congenital malformations in the fetus. The acetylator phenotype of normal caucasian control women and of mothers of malformed children was established by measuring urinary sulphadimidine and its acetylated metabolite. A further control group was the fathers of the malformed newborn. The malformations studied were facial cleft, spina-bifida and congenital heart disease. The acetylator phenotype was shown not be modified by pregnancy. 49 of 100 (49%) control women were rapid acetylators. Amongst the 108 mothers of malformed babies, 56 (52.8%) were slow acetylators and 52 (47.2%) were fast acetylators, 42 out of 83 (50.5%) of the fathers of malformed were slow acetylators and 41 (49.5%) were fast acetylators. Thus, the acetylator phenotype of the mothers of malformed children is no different from the acetylator phenotype of controls.
    Type of Medium: Electronic Resource
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