Publication Date:
1985-02-01
Description:
Two surface antigens were isolated from young or adult schistosomes by affinity chromatography with monoclonal antibodies. Vaccination with an antigen having a molecular weight of 155,000 gave partial protection against challenge in some batches of mice and in a group of cynomolgus monkeys. Vaccination with an antigen having a molecular weight of 53,000 gave similar levels of protection in mice. The results demonstrate that protection can be obtained with single antigens, but the precise requirements for reproducible vaccination are as yet unknown.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, M A -- Clegg, J A -- New York, N.Y. -- Science. 1985 Feb 1;227(4686):535-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966161" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal
;
Antigens, Helminth/*immunology/isolation & purification
;
Antigens, Surface/*immunology/isolation & purification
;
Chromatography, Affinity
;
Immunoglobulin E/biosynthesis
;
Immunoglobulin G/biosynthesis
;
Immunoglobulin M/biosynthesis
;
Macaca fascicularis
;
Macrophage Activation
;
Mice
;
Molecular Weight
;
Schistosoma mansoni/*immunology
;
Schistosomiasis/immunology/*prevention & control
;
*Vaccination
;
Vaccines
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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