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  • Springer  (18)
  • Wiley  (3)
  • American Chemical Society
  • American Geophysical Union
  • 1985-1989  (21)
  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The anonymous DNA probe L32, which defines the D8S48 locus within the Langer-Giedion syndrome chromosome region on the long arm of chromosome 8, was used to search for a common restriction fragment length polymorphism. A HindIII and an MspI polymorphism were detected (polymorphism information contents 0.25 and 0.19, respectively). Both polymorphisms were informative in the family of a Langer-Giedion patient carrying a de novo interstitial deletion 8q23-24.1. Lack of transmission of a maternal haplotype indicates that this deletion occurred during maternal gametogenesis. This finding contrasts with the frequent paternal origin of mutations in other microdeletion syndromes.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1041
    Keywords: diethyldithiocarbamate (DTC) ; human immunodeficiency virus (HIV) ; plasma membrane fluidity ; fluorescence anisotropy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In seeking the putative mechanism of action of diethyldithiocarbamate (DTC) on the immune status of HIV infected patients, the plasma membrane fluidity of peripheral blood lymphocytes (PBL) from DTC-treated and untreated patients (CDC III-IVc1) was determined. Anisotropy values of the fluorescent probe 6-(9-anthroyloxy) stearic acid were increased in DTC-treated patients (0.175 vs 0.161), indicating decreased PBL plasma membrane fluidity. The membrane rigidifying effect was significantly greater 4 h after i.v. drug administration (0.185 in treated patients). As the membrane fluidity and the function of membrane embedded antigen are interdependent, it is possible that alterations in biophysical and/or biochemical properties of membranes may account for the beneficial effect of DTC on the immune function and clinical status of HIV infected patients.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Boundary layer meteorology 42 (1988), S. 337-369 
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Modification of a turbulent flow due to a change from a smooth to a rough surface has been studied by means of a stream function-vorticity model. Results of four models of eddy viscosity (or turbulent exchange coefficient) K mhave been compared. The models are: (1) K m = l2S, where l is the mixing length and S is the deformation of mean flow; (2) K m ∼ E/S, which is based on the assumption that turbulent momentum flux is proportional to turbulent kinetic energy E; (3) K m ∼ lE1/2, the so called Prandtl-Kolmogoroff approach; and (4) K m ∼ E2/ɛ, the E — ɛ closure, where ɛ is the dissipation of turbulent kinetic energy. It is found that net-production, i.e., the difference of production and dissipation of turbulent kinetic energy counteracts the influence of mean shear on turbulent shear stress and diminishes turbulent shear stress. The reduction of mixing-length, being predicted by Model 4 only, adds to this attenuation. As a consequence, in Models 2 and 4, loss of horizontal mean momentum is concentrated close to the ground, which results in an inflexion point in the logarithmic, vertical profile of horizontal mean velocity. By contrast, in Models 1 and 3, modification of turbulent shear stress reaches larger heights causing deeper internal boundary layers. Concerning the existence of an inflexion point in U(lnz), the depth of the internal boundary layer for mean velocity, and the modification of bottom shear stress, Model 4 comes closest to experimental data. A remarkable difference of Models 1, 2, 3 and Model 4 is that only Model 4 predicts a very slow relaxation of eddy viscosity which can be attributed to the reduction of mixing-length.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Boundary layer meteorology 33 (1985), S. 151-172 
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The spectral equations of turbulent kinetic energy and temperature variance have been solved by using Onsager's energy cascade model and by extending Onsager's model to closure of terms that embody the interaction of turbulent and mean flow. The spectral model yields the following results: In a stably stratified shear flow, the peak wave numbers of the spectra of energy and temperature variance shift toward larger wave numbers as stability increases. In an unstably stratified flow, the peak wave numbers of energy spectra move toward smaller wave numbers as instability increases, whereas the opposite trend is observed for the peak wave numbers of temperature variance spectra. Hence, the peak wave numbers of temperature spectra show a discontinuity at the transition from stable to unstable stratification. At near neutral stratification, both spectra reveal a bimodal structure. The universal functions of the Monin-Obukhov similarity theory are predicted to behave as Φ m ~ Φ H ~ (- Z/L)-1/3 in an extremely unstable stratification and as Φ m ~ Φ H ~ z/L in an extremely stable stratification. For a stably stratified flow, a constant turbulent Prandtl number is expected.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Boundary layer meteorology 33 (1985), S. 233-243 
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract From measured one-dimensional spectra of velocity and temperature variance, the universal functions of the Monin-Obukhov similarity theory are calculated for the range −2 z/L + 2. The calculations show good agreement with observations with the exception of a range −1 z/L 0 in which the function Φ m , i.e., the nondimensional mean shear, is overestimated. This overestimation is shown to be caused by neglecting the spectral divergence of a vertical transport of turbulent kinetic energy. The integral of the spectral divergence over the entire wave number space is suggested to be negligibly small in comparison with production and dissipation of turbulent kinetic energy.
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  • 6
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The effect of attrition milling and post-sintering heat treatment on the fabrication, phase relations, microstructure and properties of ZrO2 (+2.3vol% Y2O3) powder used to produce a transformation toughened material was examined. Powder used to fabricate the unmilled material was treated and consolidated by a colloidal method. The same powder, treated and consolidated by the same method, but ball milled in a commercial alumina mill before consolidation, was used to fabricate the milled material. Both materials were sintered at 1400° C for 1 h and then heat treated at higher temperatures. Milling introduced Al2O3 inclusions (〈 1 vol%) and a glass phase (7 to 10 vol%). The milled powder was more difficult to sinter and exhibited more bloating (density decrease) during subsequent heat treatment. Transmission electron microscopy observations indicated that the larger glass content of the milled material beneficially reduced residual stresses that arose due to thermal contraction anistropy. Post-sintering heat treatment at temperatures 〉 1450° C produced detectable amounts of cubic ZrO2 consistent with previously reported phase studies of the ZrO2-Y2O3 system. The development of a bimodal grain structure was concurrent with the formation of detectable cubic phase. The larger grains in this bimodal distribution were primarily observed on the external surface and co-ordinating pores produced during the post-sintering heat treatments which were responsible for the bloating phenomenon. It is hypothesized that the pores were produced by the release of high pressure oxygen during cubic phase formation. Both fracture toughness (K c) and hardness of the as-sintered materials were unaffected by milling. Hardness decreased with bloating and the decrease was more pronounced for the milled material which exhibited more bloating.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Boundary layer meteorology 40 (1987), S. 31-86 
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Modification of a turbulent flow upstream of a change in surface roughness has been studied by means of a stream function-vorticity model. A flow reduction is found upstream of a step change in surface roughness when a fluid flows from a smooth onto a rough surface. Above that layer and above the region of flow reduction downstream of a smooth-rough transition, a flow acceleration is observed. Similar flow modification can be seen at a rough-smooth transition with the exception that flow reduction and flow acceleration are reversed. Within a fetch of −500 〈 x/z 0〈 + 500 (z 0 is the maximum roughness length, the roughness transition is located at x/z 0 = 0), flow reduction (flow acceleration) upstream of a roughness transition is one order of magnitude smaller than the flow reduction (flow acceleration) downstream of a smooth-rough (rough-smooth) transition. The flow acceleration (flow reduction) above that layer is two orders of magnitude. The internal boundary layer (IBL) for horizontal mean velocity extends to roughly 300z 0 upstream of a roughness transition, whereas the IBL for turbulent shear stress as well as the distortion of flow equilibrium extend almost twice as far. For the friction velocity, an undershooting (overshooting) with respect to upstream equilibrium is predicted which precedes overshooting (undershooting) over new equilibrium just behind a roughness transition. The flow modification over a finite fetch of modified roughness is weaker than over a corresponding fetch downstream of a single step change in roughness and the flow stays closer to upstream equilibrium. Even in front of the first roughness change of a finite fetch of modified roughness, a distortion of flow equilibrium due to the second, downwind roughness change can be observed.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Boundary layer meteorology 44 (1988), S. 411-413 
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Jackson and Hunt's (1975) equation for the depth of the inner layer of flows over low hills does not depend on any closure assumption as contrarily supposed in literature. This equation contains a constant which can arbitrarily be specified. It is suggested that this ‘inner-layer constant’ should be determined from experimental data. A preliminary check with some data from the Askervein experiment suggests that Jackson and Hunt's equation fits these data almost as well as Jensen's equation provided that fitted ‘inner-layer constants’ are used.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Boundary layer meteorology 48 (1989), S. 431-442 
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Numerical simulations are used to study neutral surface-layer flow which passes over isolated or widely separated strips of modified roughness embedded in an otherwise homogeneous surface. Simple power laws are given for the maximum height and horizontal extent of turbulent momentum and horizontal mean velocity wakes with an assessment of the range of validity of this proposal. Furthermore, it is indicated, how vertical profiles of energy budget and horizontal mean velocity are distorted by a roughness strip.
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  • 10
    Publication Date: 1986-03-01
    Print ISSN: 0022-2461
    Electronic ISSN: 1573-4803
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Springer
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