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  • pharmacokinetics  (4)
  • 23.20  (3)
  • Springer  (7)
  • American Association of Petroleum Geologists
  • American Chemical Society
  • 1985-1989  (7)
Collection
Keywords
Publisher
  • Springer  (7)
  • American Association of Petroleum Geologists
  • American Chemical Society
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of radio-labeled iloprost in elderly volunteers (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 597-605 
    Details
    ISSN: 1432-1041
    Keywords: iloprost ; prostacyclin analogue ; pharmacokinetics ; pharmacodynamics ; radiolabeled study ; volunteers ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels and excretion of tritium-labeled iloprost in healthy elderly male and female volunteers have been measured after i.v. infusion of 2 ng·kg−1·min−1 for 4 h and oral administration of 0.1 and 0.48 μg/kg. During infusion, a steady-state of labeled compounds in the plasma was not achieved. Total radioactivity declined from a mean of 408 pg equiv/ml in three phases, with half-lives of 24 min, 1.7 h and 5.0 h, respectively. A steady-state of unchanged iloprost was reached rapidly with a peak of 81 pg/ml. Plasma levels declined biphasically with half-lives of 6 min and 31 min. Total clearance was 24 ml· min−1·kg−1. Maximum concentrations of labeled substances after oral administration were 307 and 1,051 pg equiv/ml after 29 and 39 min respectively. The peak of unchanged iloprost (116 pg/ml) was observed 7.5 min after an oral dose of 0.48 μg/kg. Bioavailability was 16%. Iloprost was totally metabolized and the metabolities were mainly excreted in urine. The main biotransformation products in plasma and urine were tentatively identified by cochromatography as dinor-and tetranoriloprost and their glucuronides. ADP-induced platelet aggregation was reduce by 60% during the i.v. infusion and 15 min after oral administration of 0.48 μg/kg. Heart rate and blood pressure were virtually unaffected. Common side-effects were facial flush, headache and nausea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02455995
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  • 2
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 357-362 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; enprofylline ; liver cirrhosis ; renal failure ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis, patients with chronic renal failure, and healthy subjects, and have assessed the predictive value of routine tests of liver function and renal function (creatinine clearance) for theophylline and enprofylline total body clearances. Theophylline clearance was significantly decreased in the patients with liver cirrhosis compared with both the patients with renal failure and the healthy subjects (the mean values in the three groups were 24, 47, and 46 ml·h−1·kg−1 respectively. Enprofylline clearance was significantly decreased in the patients with chronic renal failure, compared with both the patients with liver cirrhosis and the healthy subjects (the values in the three groups were 64, 250, and 289 ml·h−1·kg−1 respectively. There was a strong correlation between creatinine clearance and enprofylline clearance, while there was only a poor correlation between the liver function tests and theophylline clearance. It appears that in various clinical situations enprofylline elimination can be predicted more precisely than theophylline elimination, which may make the drug safer in clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561364
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  • 3
    Electronic Resource
    Electronic Resource
    Nisoldipine: Kinetics and effects on blood pressure and heart rate in patients with liver cirrhosis after intravenous and oral administration (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 387-394 
    Details
    ISSN: 1432-1041
    Keywords: nisoldipine ; cirrhosis ; pharmacokinetics ; blood pressure ; heart rate ; calcium entry blocker ; concentration-effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and effects on blood pressure and heart rate of nisoldipine were studied in 8 patients with cirrhosis and in 8 age-matched healthy controls. On separate occasions each subject received nisoldipine by i.v. infusion (0.37 mg in 40 min) and as a tablet (5 mg for patients and 20 mg for control subjects). After i.v. nisoldipine, the elimination half-life was 9.7 h in control subjects and 16.6 h in the cirrhotics. The volume of distribution was 4.1 l/kg and 6.4 l/kg and the total systemic clearance was 847 ml/min and 494 ml/min, respectively. On oral nisoldipine, systemic availability was fourfold higher in patients with cirrhosis: 14.7% versus 3.7%. After i.v. administration of nisoldipine there was a brief decrease in systolic and diastolic blood pressure in both groups, whereas the heart rate increased. After 4 h a second effect peak appeared in the control subjects. After oral nisoldipine similar effect-time profiles were found, but effects lasted longer than after i.v. administration. Comparison of the maximal total plasma concentration of nisoldipine and the maximal effect in the two groups revealed that sensitivity to nisoldipine was not different in patients with cirrhosis. A reduction in the dose of nisoldipine is recommended when cirrhotics require oral nisoldipine in therapeutic practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542441
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 61-68 
    Details
    ISSN: 1432-1041
    Keywords: iloprost ; prostacyclin analogue ; pharmacokinetics ; platelet aggregation ; healthy male volunteers ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels of the prostacyclin analogue, iloprost, were measured by antibody/GC/MS in healthy male volunteers given 1 and 3 ng/kg per min i.v. for 45 min, and 1 µg/kg p.o. Following i.v. infusion, the steady-state plasma levels of iloprost were strictly dose-dependent (46±8 pg/ml and 135±24 pg/ml). The disposition was biphasic with half-lives of 3–4 min and 0.5 h. After oral administration, absorption of the drug was extremely rapid, the maximum plasma level of 251±32 pg/ml being achieved after 10±6 min. The bioavailability was 16±4%. Platelet aggregation induced by 2 µM ADP was reduced by 53% and 68% at the end of the two different infusions, and by 68% 15 min after p.o. administration. The ex-vivo inhibition of platelet aggregation by iloprost was not affected by preceding drug treatment. The cAMP content of platelets was increased by a factor of 2.5 at the end of the infusions and to a lesser extent 15 min after oral dosing. A slight increase in heart rate occurred during the infusion and within 30 min after oral administration; blood pressure was virtually unaffected. Except for transient side-effects (facial flush and headache) no adverse reactions were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614197
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  • 5
    Electronic Resource
    Electronic Resource
    Gyromagnetic ratios of 4+ and 6+ states in156Gd and158Gd (1988)
    Springer
    The European physical journal 331 (1988), S. 277-286 
    Details
    ISSN: 1434-601X
    Keywords: 23.20 ; 27.70
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The followingg-factors have been derived from time integral measurements of γ-γ angular correlations in the static magnetic hyperfine field of magnetized gadolinium metal probes:156Gd:g(4 1 + )=+0.310(19)g(6 1 + )=+0.25(21)g(4 3 + , 1511 keV)=+0.809(27)158Gd:g(4 1 + )=+0.409(15). The 5.35d 156Tb sources were produced by the reaction156Gd(d, 2n)156Tb in our cyclotron. A carrier-free 150y 158Tb source was obtained from ISOLDE/CERN. In comparison with the precisely knowng-factors of the 2 1 + states,g(2 1 su+ ,156Gd) =+0.386(4) andg(2 1 + ,158Gd)=0.381(4), we observe a large reduction for the156Gd 4 1 + state whereasg increases slightly for158Gd. The half-life of the 4 1 + state of158Gd was remeasured as158Gd:T 1/2(4 1 + )=148(2) ps. A measurement of the rotation in the 4 3 + state of156Gd in external magnetic fields of various strengths up toB ext=9.5 T did not confirm the anomalous dependence of the magnetic hyperfine field in gadolinium metal on the external field, which has been reported by Persson et al. [29].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01355597
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  • 6
    Electronic Resource
    Electronic Resource
    Conversion processes in superheavy and giant atoms (1986)
    Springer
    The European physical journal 323 (1986), S. 139-155 
    Details
    ISSN: 1434-601X
    Keywords: 23.20 ; 25.70 ; 36.90
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Conversion of bound state electrons and internale +,e −-pair creation in superheavy and giant atoms are investigated. We consider various nuclear transitions of multipolaritiesE0, EL andML (L≧1) in superheavy atoms with Z〉109. We are concerned in particular with the pecularities of conversion processes in supercritical systems. Our theoretical studies are confronted with the prominent peak structures observed in positron spectra of very heavy collision systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01290305
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  • 7
    Electronic Resource
    Electronic Resource
    Yrast states in81Br and82Br (1986)
    Springer
    The European physical journal 324 (1986), S. 127-137 
    Details
    ISSN: 1434-601X
    Keywords: 21.10 ; 23.20 ; 27.50+e
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Levels in81Br and82Br have been investigated up to spin 21/2 and 10ħ, respectively, on the basis of in-beamγ-ray spectroscopy inα and deuteron induced reactions. In81Br a 3-quasiparticle (qp) band built on a (13/2−) level at 2.55 MeV has been established besides the bands built on thep 3/2 andg 9/2 proton excitations. The 3qp configuration is interpreted to include at least oneg 9/2 proton. The structures observed in the doublyodd nucleus82Br are associated withg 9/2 proton and/or neutron excitations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01325124
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