Publication Date:
1989-09-22
Description:
The human immunodeficiency virus (HIV) binds to CD4-positive cells through interaction of its envelope glycoprotein (gp120) with the CD4 molecule. CD4 is a prominent immunoregulatory molecule, and chronic exposure to antibody against CD4 (anti-CD4) has been shown to cause immunodeficiency in mice. T cell-dependent in vitro immune responses can also be inhibited by anti-CD4. Experimental findings reported here indicate that CD4-bound gp120 attracts gp120-specific antibodies derived from the blood of HIV-seropositive individuals to form a trimolecular complex with itself and CD4. Thus targeted to CD4, the gp120-specific antibody functions as an antibody to CD4; it cross-links and modulates the CD4 molecules and suppresses the activation of T cells as measured by mobilization of intracellular calcium (Ca2i+). The synergism between gp120 and anti-gp120 in blocking T cell activation occurs at low concentrations of both components. Neither gp120 nor anti-gp120 inhibits T cell activation by itself in the concentrations tested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mittler, R S -- Hoffmann, M K -- New York, N.Y. -- Science. 1989 Sep 22;245(4924):1380-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bristol-Myers Company, Wallingford, CT 06492.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2571187" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/*immunology
;
Antigen-Antibody Reactions
;
Antigens, Differentiation, T-Lymphocyte/*immunology
;
CD4-Positive T-Lymphocytes/*immunology
;
Calcium/physiology
;
Dose-Response Relationship, Immunologic
;
HIV/*immunology
;
HIV Antibodies/*immunology
;
HIV Antigens/*immunology
;
HIV Envelope Protein gp120
;
Humans
;
Immunologic Capping
;
Lymphocyte Activation
;
Receptors, Antigen, T-Cell/immunology
;
Retroviridae Proteins/*immunology
;
Viral Envelope Proteins/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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