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  • Amino Acid Sequence  (2)
  • Molecular Sequence Data  (2)
  • exploratory behavior  (2)
  • American Association for the Advancement of Science (AAAS)  (2)
  • Springer  (2)
  • Springer Nature
  • 1985-1989  (4)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (2)
  • Springer  (2)
  • Springer Nature
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 16 (1986), S. 281-284 
    ISSN: 1573-3297
    Keywords: inbred strain ; substrains ; mice ; exploratory behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Adult male mice from the substrains DBA/2JNmg and DBA/2J were individually placed into a novel environment and compared for nine behavioral components. The substrains differed in three vertically oriented exploratory acts, the latter showing the highest rates. On the basis of the breeding history of strain DBA/2, it is concluded that over the past years one or more mutations with an effect on behavior have occurred in at least these sublines of an old and widely used inbred mouse strain.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 19 (1989), S. 685-700 
    ISSN: 1573-3297
    Keywords: agonistic behavior ; exploratory behavior ; hierarchical relations ; inbred strains ; kin recognition ; Landau index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract An experiment involving trios of juvenile mice of two inbred strains (C57/ BL/6 and 129/SV) was used to test for effects of interaction between strains on levels of exploratory/agonistic behavior and on the form of asymmetric social relations. Each trio consisted of two same-sexfull siblings from the same litter and a third, unfamiliar individual (the “stranger”) which was of the same sex as the siblings and was either of the same strain as the siblings or of the other strain. Levels of exploratory/ agonistic behavior between the siblings and the stranger, both in the initial encounter and after 3 or more days, were higher in mixed-strain trios than in same-strain trios, and hierarchies formed on the basis of these behaviors were significantly more linear in mixed-strain trios than in same-strain trios. Although some absolute differences between the strains were detectable, the most marked behavioral differences were between mixed-strain and same-strain trios.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 1989-11-03
    Description: A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells. The cDNA encodes a protein of 230 amino acids with a molecular mass of 26.182 daltons. The human protein is very similar to the bovine homolog, with only three amino acids differing in over 100 residues compared. The amino acid sequence deduced from the cDNA was 54% identical to that of the neuron-specific protein PGP 9.5. Purification of bovine PGP 9.5 confirmed that it is also a ubiquitin carboxyl-terminal hydrolase. These results suggest that a family of such related proteins exists and that their expression is tissue-specific.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilkinson, K D -- Lee, K M -- Deshpande, S -- Duerksen-Hughes, P -- Boss, J M -- Pohl, J -- New York, N.Y. -- Science. 1989 Nov 3;246(4930):670-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2530630" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; B-Lymphocytes/enzymology ; Base Sequence ; Cattle ; DNA/genetics ; Humans ; Isoenzymes/genetics ; Molecular Sequence Data ; Neuropeptides/*genetics/isolation & purification ; Sequence Homology, Nucleic Acid ; Thiolester Hydrolases/*genetics/isolation & purification ; Ubiquitin Thiolesterase
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1988-12-23
    Description: Hypocalcemic vitamin D-resistant rickets is a human genetic disease resulting from target organ resistance to the action of 1,25-dihydroxyvitamin D3. Two families with affected children homozygous for this autosomal recessive disorder were studied for abnormalities in the intracellular vitamin D receptor (VDR) and its gene. Although the receptor displays normal binding of 1,25-dihydroxyvitamin D3 hormone, VDR from affected family members has a decreased affinity for DNA. Genomic DNA isolated from these families was subjected to oligonucleotide-primed DNA amplification, and each of the nine exons encoding the receptor protein was sequenced for a genetic mutation. In each family, a different single nucleotide mutation was found in the DNA binding domain of the protein; one family near the tip of the first zinc finger (Gly----Asp) and one at the tip of the second zinc finger (Arg----Gly). The mutant residues were created in vitro by oligonucleotide directed point mutagenesis of wild-type VDR complementary DNA and this cDNA was transfected into COS-1 cells. The produced protein is biochemically indistinguishable from the receptor isolated from patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, M R -- Malloy, P J -- Kieback, D G -- Kesterson, R A -- Pike, J W -- Feldman, D -- O'Malley, B W -- New York, N.Y. -- Science. 1988 Dec 23;242(4886):1702-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2849209" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Calcitriol/metabolism ; Cell Line ; Cell Line, Transformed ; Codon ; DNA/genetics/metabolism ; Exons ; Female ; Gene Amplification ; Homozygote ; Humans ; Hypocalcemia/*genetics ; Immunoblotting ; Male ; Molecular Sequence Data ; *Mutation ; Receptors, Calcitriol ; Receptors, Steroid/*genetics/metabolism ; Rickets/*genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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