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  • Articles  (3)
  • General Chemistry  (2)
  • CHIP  (1)
  • 1985-1989  (3)
  • 1910-1914
  • 1905-1909
  • 1
    ISSN: 1573-0646
    Keywords: breast cancer ; Iproplatin ; CHIP ; phase II study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-five women with advanced breast cancer were treated in a phase II trial of iproplatin 275 mg/m2 administered intravenously every 4 weeks. All patients had measurable or evaluable indicator lesions, and had undergone treatment with no more than one previous chemotherapy regimen, including adjuvant chemotherapy. Two of the twenty-four evaluable patients (8%) experienced major therapeutic responses. One patient had a complete regression of pulmonary nodules lasting 18 + months; another had a partial regression of metastatic disease in the liver (4 months). The inevaluable patient was ineligible for the study because of previous radiation to the indicator lesions on her chest wall; nonetheless, she experienced a 10 month partial regression of those nodules. Myelosuppression was generally dose limiting; thrombocytopenia was more profound, but leukopenia was more prolonged. Nausea, vomiting, diarrhea, and general malaise were prominent toxicities, and led to discontinuation of therapy in 4 patients. Iproplatin has limited activity in previously treated women with advanced breast cancer.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 97 (1985), S. 745-760 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es ist schon sehr lange bekannt, daß sich manche Übergangsmetallsulfide in wäßrigem Ammoniumpolysulfid lösen. Obwohl anzunehmen war, daß sich dabei Metallpolysulfide bilden, hat man sich diesem Verbindungstyp erst in den letzten Jahren intensiver zugewandt. Dabei konnte eine Fülle neuer Komplexe mit Polysulfido-Chelatliganden Sn2- (n=2,3,4…) isoliert und charakterisiert werden. Die Komplexe interessieren bezüglich ihrer Struktur und Reaktivität, aber auch im Hinblick auf mögliche Anwendungen; mit ihnen können Schwefelringe definierter Größe gezielt hergestellt werden, und es deutet sich an, daß sie auch in der Katalyse Verwendung finden könnten.
    Additional Material: 26 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 24 (1985), S. 742-757 
    ISSN: 0570-0833
    Keywords: Polysulfides ; Transition metals ; Chelates ; Sulfides ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: It has been long known that certain transition metal sulfides dissolve in aqueous ammonium polysulfide. Although it was assumed that they thereby formed metal polysulfides, attention was first paid to such compounds only a few years ago. In recent years a host of new complexes with polysulfido chelate ligands have been isolated and characterized. The complexes are of interest not only regarding their structure and reactivity but also in view of their potential uses; they can be used for the directed preparation of sulfur rings of a given size, and there are indications that they will find applications in catalysis.
    Additional Material: 26 Ill.
    Type of Medium: Electronic Resource
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