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  • 1
    Publication Date: 1987-03-20
    Description: The thymidine kinase (tk) promoter of herpes simplex virus includes an octanucleotide sequence motif (ATTTGCAT) that is also an essential component of immunoglobulin kappa gene promoters. In the absence of an enhancer, tk promoter derivatives that contain this element support a higher rate of transcription than those that lack it. The action of the kappa enhancer augments that of the octanucleotide in B lymphoid cells; when both elements are present, tk promoter activity is increased by more than an order of magnitude. In contrast, the presence of the octanucleotide in this promoter markedly reduces its response to a nonimmunoglobulin enhancer. These results suggest that the octanucleotide may mediate a selective interaction among promoters and enhancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parslow, T G -- Jones, S D -- Bond, B -- Yamamoto, K R -- AI22536/AI/NIAID NIH HHS/ -- CA20535/CA/NCI NIH HHS/ -- CM07810/CM/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Mar 20;235(4795):1498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3029871" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Viral/genetics ; *Enhancer Elements, Genetic ; *Gene Expression Regulation ; *Genes, Regulator ; Immunoglobulin kappa-Chains/*genetics ; Lymphocytes/physiology ; Moloney murine sarcoma virus/genetics ; *Promoter Regions, Genetic ; Simplexvirus/genetics ; Thymidine Kinase/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    In:  Other Sources
    Publication Date: 2011-08-19
    Description: A transformation of the differential equations of motion of the two-body problem in the spherical coordinates to oscillator form is derived. It is shown that the independent variable transformation dt/ds = r squared is a transformation which makes the oscillator form possible.
    Keywords: ASTRONOMY
    Type: Celestial Mechanics (ISSN 0008-8714); 35; 1-7
    Format: text
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  • 3
    Publication Date: 2019-07-13
    Description: Blue stragglers are stars, found usually in either open or globular clusters, that appear to lie on the main sequence, but are brighter and bluer than the cluster turn-off. Currently, two rival models are invoked to explain this apparently pathological behavior: internal mixing (so that fresh fuel is brought into the stellar core); and mass transfer (by which a normal main sequence star acquires mass from an evolving nearby companion and so moves up the main sequence). The latter model predicts that in the absence of complete mass transfer (i.e., coalescence), blue stragglers should be binary systems with the fainter star in a post-main sequence evolutionary state. It is important to ascertain the cause of this phenomenon since stellar evolution models of main sequence stars play such a vital role in astronomy. If mass transfer is involved, one may easily exclude binaries from age determinations of clusters, but if mixing is the cause, our age determinations will be much less accurate unless we can determine whether all stars or only some mix, and what causes the mixing to occur at all.
    Keywords: ASTRONOMY
    Type: NASA-CR-179865 , NAS 1.26:179865
    Format: application/pdf
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